A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

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Science Advances  24 Aug 2018:
Vol. 4, no. 8, eaat2720
DOI: 10.1126/sciadv.aat2720

Article Information

vol. 4 no. 8

Online ISSN: 
  • Received for publication February 9, 2018
  • Accepted for publication July 17, 2018

Author Information

  1. Haigang Song1,2,
  2. Niels S. van der Velden3,
  3. Sally L. Shiran1,
  4. Patrick Bleiziffer4,
  5. Christina Zach3,
  6. Ramon Sieber3,
  7. Aman S. Imani5,
  8. Florian Krausbeck4,
  9. Markus Aebi3,
  10. Michael F. Freeman5,
  11. Sereina Riniker4,*,
  12. Markus Künzler3,* and
  13. James H. Naismith2,6,7,*
  1. 1Biomedical Sciences Research Complex, North Haugh, University of St. Andrews, Fife KY16 9ST, UK.
  2. 2Division of Structural Biology, Wellcome Trust Centre of Human Genomics, Roosevelt Drive, Oxford OX3 7BN, UK.
  3. 3Institute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.
  4. 4Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.
  5. 5Department of Biochemistry, Molecular Biology, and Biophysics, and BioTechnology Institute, University of Minnesota–Twin Cities, St. Paul, MN 55108, USA.
  6. 6State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
  7. 7Research Complex at Harwell, Rutherford Laboratory, Didcot, Oxfordshire OX11 0FA, UK.
  1. *Corresponding author. Email: sriniker{at} (S.R.); mkuenzle{at} (M.K.); naismith{at} (J.H.N.)


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