Research ArticleHEALTH AND MEDICINE

Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos

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Science Advances  22 Aug 2018:
Vol. 4, no. 8, eaat6224
DOI: 10.1126/sciadv.aat6224

Article Information

vol. 4 no. 8

Online ISSN: 
History: 
  • Received for publication March 18, 2018
  • Accepted for publication July 18, 2018
  • .

Author Information

  1. Beste Mutlu1,
  2. Huei-Mei Chen1,
  3. James J. Moresco2,*,
  4. Barbara D. Orelo2,
  5. Bing Yang3,
  6. John M. Gaspar4,
  7. Sabine Keppler-Ross1,,
  8. John R. Yates III2,
  9. David H. Hall5,
  10. Eleanor M. Maine3 and
  11. Susan E. Mango1,,
  1. 1Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  2. 2Department of Chemical Physiology, The Scripps Research Institute, La Jolla, San Diego, CA 92037, USA.
  3. 3Department of Biology, Syracuse University, Syracuse, NY 13244, USA.
  4. 4Informatics Group, Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA.
  5. 5Center for C. elegans Anatomy, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  1. Corresponding author. Email: smango{at}mcb.harvard.edu
  • * Present address: Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

  • Present address: Biozentrum, University of Basel, 4056 Basel, Switzerland.

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