Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo

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Science Advances  22 Aug 2018:
Vol. 4, no. 8, eaat7314
DOI: 10.1126/sciadv.aat7314

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  • Deuterium and metabolic water matter – what this means biochemically and clinically
    • Laszlo G. Boros, Professor of Pediatrics/M.D., Harbor-UCLA Medical Center and the Clinical & Translational Science Institute at LABIOMED
    • Other Contributors:
      • T. Que Collins, Chief Scientist/Ph.D. in immunology and cell physiology, Centers for Deuterium Depletion, Brentwood, CA, USA
      • Eszter A. Boros, Visual aid/peak integration/B.S. in mathematics, Centers for Deuterium Depletion, Brentwood, CA, USA
      • Ferenc Lantos, Natural isotope variations in plant products/Ph.D. in biology, Department of Agriculture, University of Szeged, Szeged, Hungary
      • Gabor Somlyai, Deuterium biology/Ph.D. in biology, HYD, LLC for Cancer Research & Drug Development

    In the August 22 issue of Science Advances de Feyter et al. published an excellent paper about the cross deuteration of intermediary metabolites at steady-state (90-120 minutes) from orally consumed or infused [6,6′-2H2]glucose in models of glioblastoma multiforme (1). Two deuterated products of the tracer glucose, lactate formed via glycolysis as well as glutamate/glutamine (Glx) formed from deuterated citrate, are utilized for building 3D magnetic resonance images of brain tumors using respective radio frequencies for deuterated lactate and Glx during data acquisition. The method offers many advantages: 1) data acquisition sequences do not require additional radio frequency (RF) pulses for protonated water (1H2O) suppression; 2) there is no need for outer volume suppression to exclude potentially large signals from protonated lipids in adjacent brain tissues; and 3) deuterium metabolic imaging (DMI) is virtually unaffected by the known inhomogeneity of the magnetic field. The authors rightfully claim that deuterium metabolic imaging is well suited for widespread uses in research and the clinic.

    The quantification of deuterated lactate and glutamate are very strong advancements for the field, yet this step requires correction factors in order to account for losses of 2H from [6,6′-2H2]glucose during metabolism. Net losses occur during the transfer and/or exchanges of specific deuterons throughout intermediary metabolism. Tracer loss in the in vivo experiment is in...

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    Competing Interests: None declared.

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