Research ArticleIMMUNOLOGY

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

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Science Advances  05 Sep 2018:
Vol. 4, no. 9, eaar8320
DOI: 10.1126/sciadv.aar8320

Article Information

vol. 4 no. 9

Online ISSN: 
History: 
  • Received for publication December 21, 2017
  • Accepted for publication July 23, 2018
  • .

Author Information

  1. Catherine A. Loynes1,
  2. Jou A. Lee1,
  3. Anne L. Robertson1,2,
  4. Michael JG. Steel1,
  5. Felix Ellett1,3,
  6. Yi Feng4,
  7. Bruce D. Levy5,
  8. Moira K.B. Whyte4 and
  9. Stephen A. Renshaw1,*
  1. 1The Bateson Centre, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK.
  2. 2Division of Hematology/Oncology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  3. 3BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, Boston, MA 02129, USA.
  4. 4Medical Research Council Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  5. 5Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  1. *Corresponding author. Email: s.a.renshaw{at}sheffield.ac.uk

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