Research ArticleCANCER

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

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Science Advances  12 Sep 2018:
Vol. 4, no. 9, eaat7828
DOI: 10.1126/sciadv.aat7828

Article Information

vol. 4 no. 9

Online ISSN: 
History: 
  • Received for publication April 4, 2018
  • Accepted for publication August 1, 2018
  • .

Author Information

  1. Charles E. Gast1,*,
  2. Alain D. Silk1,*,
  3. Luai Zarour2,*,
  4. Lara Riegler3,,
  5. Joshua G. Burkhart4,
  6. Kyle T. Gustafson5,6,
  7. Michael S. Parappilly1,
  8. Minna Roh-Johnson7,,
  9. James R. Goodman8,
  10. Brennan Olson1,
  11. Mark Schmidt1,
  12. John R. Swain1,
  13. Paige S. Davies1,
  14. Vidya Shasthri1,
  15. Shinji Iizuka1,
  16. Patrick Flynn1,
  17. Spencer Watson1,§,
  18. James Korkola3,9,
  19. Sara A. Courtneidge1,9,
  20. Jared M. Fischer5,9,10,
  21. Jerry Jaboin9,11,
  22. Kevin G. Billingsley2,9,
  23. Charles D. Lopez3,9,
  24. Julja Burchard12,,
  25. Joe Gray6,9,
  26. Lisa M. Coussens1,9,
  27. Brett C. Sheppard2,9 and
  28. Melissa H. Wong1,9,||
  1. 1Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
  2. 2Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
  3. 3Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
  4. 4Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA.
  5. 5Center for Early Detection Advanced Research, Oregon Health & Science University, Portland, OR 97239, USA.
  6. 6Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.
  7. 7Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
  8. 8Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR 97239, USA.
  9. 9Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
  10. 10Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA.
  11. 11Department of Radiation Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
  12. 12Department of Computational Biology, Oregon Health & Science University, Portland, OR 97239, USA.
  1. ||Corresponding author. Email: wongme{at}ohsu.edu
    • * These authors contributed equally to this work.

    • Present address: Division of Hematology/Oncology, Pediatrics, PO Box 800386, University of Virginia, Charlottesville, VA 22908, USA.

    • Present address: Department of Biochemistry, University of Utah, Salt Lake City, UT 94112, USA.

    • § Present address: Ludwig Center for Cancer Research of the University of Lausanne, Chemin des Boveresses 155, Epalinges VD, 1006 Lausanne, Switzerland.

    • Present address: Sera Prognostics, 2749 East Parleys Way, Suite 200, Salt Lake City, UT 84109, USA.

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