Research ArticleVIROLOGY

Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α4β7 integrin antibody

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Science Advances  09 Jan 2019:
Vol. 5, no. 1, eaat7911
DOI: 10.1126/sciadv.aat7911

Article Information

vol. 5 no. 1

Online ISSN: 
  • Received for publication April 4, 2018
  • Accepted for publication November 30, 2018

Author Information

  1. Sijia He1,2,3,*,
  2. Yajing Fu1,2,3,*,
  3. Jia Guo3,*,,
  4. Mark Spear3,
  5. Jiuling Yang3,
  6. Benjamin Trinité4,
  7. Chaolong Qin1,2,5,
  8. Shuai Fu1,2,5,
  9. Yongjun Jiang1,2,5,
  10. Zining Zhang1,2,5,
  11. Junjie Xu1,2,5,
  12. Haibo Ding1,2,5,
  13. David N. Levy4,
  14. Wanjun Chen6,
  15. Emanuel Petricoin III7,
  16. Lance A. Liotta7,
  17. Hong Shang1,2,5, and
  18. Yuntao Wu3,
  1. 1Key Laboratory of AIDS Immunology of National Health Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P. R. China.
  2. 2Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, Liaoning 110001, P. R. China.
  3. 3National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
  4. 4Department of Basic Science, New York University College of Dentistry, New York, NY 10010, USA.
  5. 5Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, P. R. China.
  6. 6Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD 20892, USA.
  7. 7Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.
  1. Corresponding author. Email: hongshang100{at} (H.S.); ywu8{at} (Y.W.)
  • * These authors contributed equally to this work.

  • Present address: Merck Research Laboratories, Merck & Co. Inc., Boston, MA 02115, USA.


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