High-throughput label-free molecular fingerprinting flow cytometry

Kotaro Hiramatsu; Takuro Ideguchi; Yusuke Yonamine; SangWook Lee; Yizhi Luo; Kazuki Hashimoto; Takuro Ito; Misa Hase; Jee-Woong Park; Yusuke Kasai; Shinya Sakuma; Takeshi Hayakawa; Fumihito Arai; Yu Hoshino; Keisuke Goda

doi:10.1126/sciadv.aau0241

Research ArticleCELL BIOLOGY

High-throughput label-free molecular fingerprinting flow cytometry

View ORCID ProfileKotaro Hiramatsu¹,²,³,*,†,
View ORCID ProfileTakuro Ideguchi²,³,⁴,*,
Yusuke Yonamine⁵,
SangWook Lee¹,
Yizhi Luo¹,
Kazuki Hashimoto¹,
View ORCID ProfileTakuro Ito¹,⁶,
Misa Hase¹,
Jee-Woong Park¹,
View ORCID ProfileYusuke Kasai⁷,
Shinya Sakuma⁷,
View ORCID ProfileTakeshi Hayakawa⁸,⁹,
View ORCID ProfileFumihito Arai⁷,⁸,
Yu Hoshino⁵ and
View ORCID ProfileKeisuke Goda¹,⁶,†

¹Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.
²Research Centre for Spectrochemistry, The University of Tokyo, Tokyo 113-0033, Japan.
³PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.
⁴Department of Physics, The University of Tokyo, Tokyo 113-0033, Japan.
⁵Department of Chemical Engineering, Kyushu University, Fukuoka 819-0395, Japan.
⁶Japan Science and Technology Agency, Saitama 332-0012, Japan.
⁷Department of Micro-Nano Mechanical Science and Engineering, Nagoya University, Aichi 464-8603, Japan.
⁸Institute of Innovation for Future Society, Nagoya University, Aichi 464-8603, Japan.
⁹Department of Precision Mechanics, Faculty of Science and Engineering, Chuo University, Tokyo 112-8551, Japan.

↵†Corresponding author. Email: hiramatsu{at}chem.s.u-tokyo.ac.jp (K.H.); goda{at}chem.s.u-tokyo.ac.jp (K.G.)

↵* These authors contributed equally to this work.

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Science Advances 16 Jan 2019:
Vol. 5, no. 1, eaau0241
DOI: 10.1126/sciadv.aau0241

Kotaro Hiramatsu

1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

2Research Centre for Spectrochemistry, The University of Tokyo, Tokyo 113-0033, Japan.

3PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.

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ORCID record for Kotaro Hiramatsu
For correspondence: hiramatsu@chem.s.u-tokyo.ac.jp goda@chem.s.u-tokyo.ac.jp

Takuro Ideguchi

2Research Centre for Spectrochemistry, The University of Tokyo, Tokyo 113-0033, Japan.

3PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.

4Department of Physics, The University of Tokyo, Tokyo 113-0033, Japan.

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Yusuke Yonamine

5Department of Chemical Engineering, Kyushu University, Fukuoka 819-0395, Japan.

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SangWook Lee

1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

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Yizhi Luo

1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

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Kazuki Hashimoto

1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

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Takuro Ito

1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

6Japan Science and Technology Agency, Saitama 332-0012, Japan.

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ORCID record for Takuro Ito

Misa Hase

1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

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Jee-Woong Park

1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

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Yusuke Kasai

7Department of Micro-Nano Mechanical Science and Engineering, Nagoya University, Aichi 464-8603, Japan.

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Shinya Sakuma

7Department of Micro-Nano Mechanical Science and Engineering, Nagoya University, Aichi 464-8603, Japan.

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Takeshi Hayakawa

8Institute of Innovation for Future Society, Nagoya University, Aichi 464-8603, Japan.

9Department of Precision Mechanics, Faculty of Science and Engineering, Chuo University, Tokyo 112-8551, Japan.

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Fumihito Arai

7Department of Micro-Nano Mechanical Science and Engineering, Nagoya University, Aichi 464-8603, Japan.

8Institute of Innovation for Future Society, Nagoya University, Aichi 464-8603, Japan.

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Yu Hoshino

5Department of Chemical Engineering, Kyushu University, Fukuoka 819-0395, Japan.

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Keisuke Goda

1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

6Japan Science and Technology Agency, Saitama 332-0012, Japan.

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ORCID record for Keisuke Goda
For correspondence: hiramatsu@chem.s.u-tokyo.ac.jp goda@chem.s.u-tokyo.ac.jp

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