Research ArticleHEALTH AND MEDICINE

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

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Science Advances  23 Jan 2019:
Vol. 5, no. 1, eaau3333
DOI: 10.1126/sciadv.aau3333

Article Information

vol. 5 no. 1

Online ISSN: 
History: 
  • Received for publication May 30, 2018
  • Accepted for publication December 11, 2018
  • .

Author Information

  1. Stephen S. Dominy1,*,,
  2. Casey Lynch1,*,
  3. Florian Ermini1,
  4. Malgorzata Benedyk2,3,
  5. Agata Marczyk2,
  6. Andrei Konradi1,
  7. Mai Nguyen1,
  8. Ursula Haditsch1,
  9. Debasish Raha1,
  10. Christina Griffin1,
  11. Leslie J. Holsinger1,
  12. Shirin Arastu-Kapur1,
  13. Samer Kaba1,
  14. Alexander Lee1,
  15. Mark I. Ryder4,
  16. Barbara Potempa5,
  17. Piotr Mydel2,6,
  18. Annelie Hellvard3,6,
  19. Karina Adamowicz2,
  20. Hatice Hasturk7,8,
  21. Glenn D. Walker9,
  22. Eric C. Reynolds9,
  23. Richard L. M. Faull10,
  24. Maurice A. Curtis11,12,
  25. Mike Dragunow11,13 and
  26. Jan Potempa2,5,*
  1. 1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
  2. 2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
  3. 3Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
  4. 4Division of Periodontology, Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
  5. 5Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
  6. 6Broegelman Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
  7. 7The Forsyth Institute, Cambridge, MA, USA.
  8. 8Harvard University School of Dental Medicine, Boston, MA, USA.
  9. 9Cooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia.
  10. 10Department of Anatomy with Radiology, Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  11. 11Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  12. 12Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  13. 13Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  1. Corresponding author. Email: sdominy{at}cortexyme.com
  • * These authors contributed equally to this work as co-senior authors.

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Jan 201941414087725540
Feb 20194086563113870
Mar 2019143239775894
Apr 2019753353904673
May 2019111132862601
Jun 201926187213599
Jul 20192386981678
Aug 201975616861

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