Research ArticleHEALTH AND MEDICINE

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

See allHide authors and affiliations

Science Advances  23 Jan 2019:
Vol. 5, no. 1, eaau3333
DOI: 10.1126/sciadv.aau3333

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all . Please read our guidelines before submitting your own eLetter.

Compose eLetter

Plain text

  • Plain text
    No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests
CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Image CAPTCHA
Enter the characters shown in the image.

Vertical Tabs

  • RE: Porphyromonas gingivalis, PKR and Alzheimer’s disease
    • Jacques Hugon, Chair Professor neurologist, University of Paris Diderot - Lariboisiere Hospital Paris France
    • Other Contributors:
      • Claire Paquet, Chair Professor neurologist, University of Paris Diderot - Lariboisiere Hospital Paris France
      • Julien Dumurgier, Associate professor neurologist, University of Paris Diderot - Lariboisiere Hospital Paris France
      • Francois Mouton Liger, Associate Professor neuroscientist, University of Paris Diderot
      • Jean Antoine Girault, Director Research Inserm, Inserm Unit UMR-S 1270

    Jacques Hugon 1, Claire Paquet 1, Julien Dumurgier 1, François Mouton Liger1, Jean-Antoine Girault 2
    1 Center of Cognitive Neurology and Inserm U1144, Lariboisière Hospital, APHP, University of Paris Diderot, Paris, France
    2 Institut du Fer à Moulin, Inserm, Sorbonne Université, UMR-S1270, Paris, France

    We read with great interest the article entitled “Porphyromonas gingivalis in Alzheimer’s disease (AD) brains: Evidence for disease causation and treatment with small-molecule inhibitors” (1) recently published in Science Advances. There is an increasing focus on the implication of innate immunity in the pathophysiology of AD and the article discusses the possible role of P. gingivalis protease gingipain in triggering innate immunity through partial proteolysis of APoE and TREM1. We would like to draw attention on an additional potential relationship. P. gingivalis was reported to activate the PKR in osteoblasts (2), a protein kinase involved in apoptosis, innate immunity and inflammation (3). We have previously shown that PKR is activated in the brain of AD patients, that the levels of activated PKR are elevated in the cerebrospinal fluid of AD patients (4, 5, 6), and that PKR knockout improves a mouse model of AD (7). Our results on PKR corroborate the findings that innate immune pathways are chronically activated in AD brain tissue. The slowly spreading invasion by P. gingivalis shown by Dominy et al. could be one of the causes triggering innate immune...

    Show More
    Competing Interests: None declared.
  • RE: Further research on microbes in Alzheimer's disease
    • Leslie C. Norins, Founder and CEO, Alzheimer's Germ Quest, Inc. (www.ALZgerm.org)

    This stimulating contribution is a welcome addition to the renaissance of research interest in infectious agents that can trigger or promote Alzheimer's disease. Unfortunately, the U.S. government's designated principal funder of Alzheimer's research, the National Institute on Aging, has so far given little encouragement and only paltry funding to such investigations. Congress's current record appropriation of $2.3 billion for NIH Alzheimer's research provides the NIA ample opportunity to make up for lost time and opportunity.

    Leslie C.Norins, MD, PhD
    Founder and CEO
    Alzheimer's Germ Quest, Inc.
    (An independent, self-funded public benefit corporation which neither solicits nor accepts outside donations or grants)
    www.ALZgerm.org
    leslie.norins@alzgerm.org
    239-649-1346
    4301 Gulfshore Blvd., Suite 1404
    Naples, FL 34103

    Competing Interests: None declared.

Navigate This Article