Research ArticleHEALTH AND MEDICINE
Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
- Stephen S. Dominy1,*,†,
- Casey Lynch1,*,
- Florian Ermini1,
- Malgorzata Benedyk2,3,
- Agata Marczyk2,
- Andrei Konradi1,
- Mai Nguyen1,
- Ursula Haditsch1,
- Debasish Raha1,
- Christina Griffin1,
- Leslie J. Holsinger1,
- Shirin Arastu-Kapur1,
- Samer Kaba1,
- Alexander Lee1,
- Mark I. Ryder4,
- Barbara Potempa5,
- Piotr Mydel2,6,
- Annelie Hellvard3,6,
- Karina Adamowicz2,
- Hatice Hasturk7,8,
- Glenn D. Walker9,
- Eric C. Reynolds9,
- Richard L. M. Faull10,
- Maurice A. Curtis11,12,
- Mike Dragunow11,13 and
- Jan Potempa2,5,*
- 1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
- 2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
- 3Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
- 4Division of Periodontology, Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
- 5Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
- 6Broegelman Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
- 7The Forsyth Institute, Cambridge, MA, USA.
- 8Harvard University School of Dental Medicine, Boston, MA, USA.
- 9Cooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia.
- 10Department of Anatomy with Radiology, Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
- 11Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
- 12Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
- 13Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
- ↵†Corresponding author. Email: sdominy{at}cortexyme.com
↵* These authors contributed equally to this work as co-senior authors.
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Science Advances 23 Jan 2019:
Vol. 5, no. 1, eaau3333
DOI: 10.1126/sciadv.aau3333
Vol. 5, no. 1, eaau3333
DOI: 10.1126/sciadv.aau3333
Stephen S. Dominy
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Casey Lynch
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Florian Ermini
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Malgorzata Benedyk
2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
3Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Agata Marczyk
2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Andrei Konradi
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Mai Nguyen
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Ursula Haditsch
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Debasish Raha
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Christina Griffin
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Leslie J. Holsinger
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Shirin Arastu-Kapur
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Samer Kaba
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Alexander Lee
1Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Mark I. Ryder
4Division of Periodontology, Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
Barbara Potempa
5Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
Piotr Mydel
2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
6Broegelman Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Annelie Hellvard
3Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
6Broegelman Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Karina Adamowicz
2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Hatice Hasturk
7The Forsyth Institute, Cambridge, MA, USA.
8Harvard University School of Dental Medicine, Boston, MA, USA.
Glenn D. Walker
9Cooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia.
Eric C. Reynolds
9Cooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia.
Richard L. M. Faull
10Department of Anatomy with Radiology, Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Maurice A. Curtis
11Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
12Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Mike Dragunow
11Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
13Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Jan Potempa
2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
5Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
