Research ArticleHEALTH AND MEDICINE

Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models

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Science Advances  16 Jan 2019:
Vol. 5, no. 1, eaau7196
DOI: 10.1126/sciadv.aau7196

Article Information

vol. 5 no. 1

Online ISSN: 
History: 
  • Received for publication July 9, 2018
  • Accepted for publication December 6, 2018
  • .

Author Information

  1. Mark Elliott1,*,
  2. Christine Favre-Guilmard2,*,
  3. Sai Man Liu1,*,
  4. Jacquie Maignel2,*,
  5. Geoffrey Masuyer3,*,
  6. Matthew Beard1,,
  7. Christopher Boone4,,
  8. Denis Carré2,,
  9. Mikhail Kalinichev2,,
  10. Stephane Lezmi2,,
  11. Imran Mir1,,
  12. Camille Nicoleau2,,
  13. Shilpa Palan1,,
  14. Cindy Perier2,,
  15. Elsa Raban2,,
  16. Sicai Zhang4,,
  17. Min Dong4,,
  18. Pål Stenmark3,5, and
  19. Johannes Krupp1,2,
  1. 1Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK.
  2. 2Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France.
  3. 3Department of Biochemistry and Biophysics, Stockholm University, Stockholm SE-106 91, Sweden.
  4. 4Department of Urology, Boston Children’s Hospital, Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Department of Experimental Medical Science, Lund University, 221 00 Lund, Sweden.
  1. Corresponding author. Email: johannes.krupp{at}ipsen.com (J.K.); min.dong{at}childrens.harvard.edu (M.D.); stenmark{at}dbb.su.se (P.S.)
  • * These authors contributed equally to this work as first authors.

  • These authors contributed equally to this work as second authors.

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