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Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

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Science Advances  23 Jan 2019:
Vol. 5, no. 1, eaau9060
DOI: 10.1126/sciadv.aau9060

Article Information

vol. 5 no. 1

Online ISSN: 
History: 
  • Received for publication July 26, 2018
  • Accepted for publication December 11, 2018
  • .

Author Information

  1. Tsuyoshi Oshima1,2,*,
  2. Yoshimi Niwa1,*,
  3. Keiko Kuwata1,
  4. Ashutosh Srivastava1,
  5. Tomoko Hyoda3,
  6. Yoshiki Tsuchiya4,
  7. Megumi Kumagai5,
  8. Masato Tsuyuguchi6,
  9. Teruya Tamaru7,
  10. Akiko Sugiyama1,
  11. Natsuko Ono1,
  12. Norjin Zolboot1,
  13. Yoshiki Aikawa1,
  14. Shunsuke Oishi1,
  15. Atsushi Nonami8,
  16. Fumio Arai9,
  17. Shinya Hagihara1,2,10,
  18. Junichiro Yamaguchi11,
  19. Florence Tama1,12,
  20. Yuya Kunisaki9,
  21. Kazuhiro Yagita4,
  22. Masaaki Ikeda5,
  23. Takayoshi Kinoshita6,
  24. Steve A. Kay1,13,
  25. Kenichiro Itami1,2,14, and
  26. Tsuyoshi Hirota1,10,
  1. 1Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan.
  2. 2Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.
  3. 3Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  4. 4Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
  5. 5Department of Physiology, Faculty of Medicine, Saitama Medical University, Saitama 350-0495, Japan.
  6. 6Graduate School of Science, Osaka Prefecture University, Osaka 599-8531, Japan.
  7. 7Department of Physiology and Advanced Research Center for Medical Science, Toho University School of Medicine, Tokyo 143-8540, Japan.
  8. 8Center for Advanced Medical Innovation, Kyushu University, Fukuoka 812-8582, Japan.
  9. 9Department of Stem Cell Biology and Medicine/Cancer Stem Cell Research, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan.
  10. 10PRESTO, JST, Nagoya 464-8601, Japan.
  11. 11Department of Applied Chemistry, Waseda University, Tokyo 169-8555, Japan.
  12. 12Department of Physics, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan, and RIKEN Center for Computational Science, Kobe 650-0047, Japan.
  13. 13Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
  14. 14ERATO Itami Molecular Nanocarbon Project, JST, Nagoya 464-8601, Japan.
  1. Corresponding author. Email: thirota{at}itbm.nagoya-u.ac.jp (T.H.); itami{at}chem.nagoya-u.ac.jp (K.I.)
  • * These authors contributed equally to this work.

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Jan 20191314185965
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Mar 201956569233
Apr 201958416140
May 201938375123
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