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Research ArticleIMMUNOLOGY
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection
- View ORCID ProfileMohammad Arifuzzaman1,
- View ORCID ProfileYuvon R. Mobley1,*,
- View ORCID ProfileHae Woong Choi2,
- Pradeep Bist3,
- Cristina A. Salinas4,
- Zachary D. Brown5,
- View ORCID ProfileSwaine L. Chen6,7,
- View ORCID ProfileHerman F. Staats2,8,9 and
- View ORCID ProfileSoman N. Abraham1,2,3,8,†
- 1Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.
- 2Department of Pathology, Duke University, Durham, NC 27710, USA.
- 3Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.
- 4Undergraduate Program in Biology, Duke University, Durham, NC 27710, USA.
- 5Undergraduate Program in Biomedical Engineering, Duke University, Durham, NC 27710, USA.
- 6Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
- 7Infectious Diseases Group, Genome Institute of Singapore, Singapore 138672, Singapore.
- 8Department of Immunology, Duke University, Durham, NC 27710, USA.
- 9Department of Medicine, Duke University, Durham, NC 27710, USA.
- ↵†Corresponding author. Email: soman.abraham{at}duke.edu
↵* Present address: Assurex Health, Mason, OH 45040, USA.
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Science Advances 02 Jan 2019:
Vol. 5, no. 1, eaav0216
DOI: 10.1126/sciadv.aav0216
Vol. 5, no. 1, eaav0216
DOI: 10.1126/sciadv.aav0216
Mohammad Arifuzzaman
1Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.
Yuvon R. Mobley
1Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.
Hae Woong Choi
2Department of Pathology, Duke University, Durham, NC 27710, USA.
Pradeep Bist
3Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.
Cristina A. Salinas
4Undergraduate Program in Biology, Duke University, Durham, NC 27710, USA.
Zachary D. Brown
5Undergraduate Program in Biomedical Engineering, Duke University, Durham, NC 27710, USA.
Swaine L. Chen
6Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
7Infectious Diseases Group, Genome Institute of Singapore, Singapore 138672, Singapore.
Herman F. Staats
2Department of Pathology, Duke University, Durham, NC 27710, USA.
8Department of Immunology, Duke University, Durham, NC 27710, USA.
9Department of Medicine, Duke University, Durham, NC 27710, USA.
Soman N. Abraham
1Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.
2Department of Pathology, Duke University, Durham, NC 27710, USA.
3Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.
8Department of Immunology, Duke University, Durham, NC 27710, USA.
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