MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

Mohammad Arifuzzaman; Yuvon R. Mobley; Hae Woong Choi; Pradeep Bist; Cristina A. Salinas; Zachary D. Brown; Swaine L. Chen; Herman F. Staats; Soman N. Abraham

doi:10.1126/sciadv.aav0216

Research ArticleIMMUNOLOGY

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

View ORCID ProfileMohammad Arifuzzaman¹,
View ORCID ProfileYuvon R. Mobley¹,*,
View ORCID ProfileHae Woong Choi²,
Pradeep Bist³,
Cristina A. Salinas⁴,
Zachary D. Brown⁵,
View ORCID ProfileSwaine L. Chen⁶,⁷,
View ORCID ProfileHerman F. Staats ²,⁸,⁹ and
View ORCID ProfileSoman N. Abraham ¹,²,³,⁸,†

¹Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.
²Department of Pathology, Duke University, Durham, NC 27710, USA.
³Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.
⁴Undergraduate Program in Biology, Duke University, Durham, NC 27710, USA.
⁵Undergraduate Program in Biomedical Engineering, Duke University, Durham, NC 27710, USA.
⁶Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
⁷Infectious Diseases Group, Genome Institute of Singapore, Singapore 138672, Singapore.
⁸Department of Immunology, Duke University, Durham, NC 27710, USA.
⁹Department of Medicine, Duke University, Durham, NC 27710, USA.

↵†Corresponding author. Email: soman.abraham{at}duke.edu

↵* Present address: Assurex Health, Mason, OH 45040, USA.

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Science Advances 02 Jan 2019:
Vol. 5, no. 1, eaav0216
DOI: 10.1126/sciadv.aav0216

Mohammad Arifuzzaman

1Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

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Yuvon R. Mobley

1Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

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Hae Woong Choi

2Department of Pathology, Duke University, Durham, NC 27710, USA.

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Pradeep Bist

3Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.

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Cristina A. Salinas

4Undergraduate Program in Biology, Duke University, Durham, NC 27710, USA.

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Zachary D. Brown

5Undergraduate Program in Biomedical Engineering, Duke University, Durham, NC 27710, USA.

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Swaine L. Chen

6Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

7Infectious Diseases Group, Genome Institute of Singapore, Singapore 138672, Singapore.

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ORCID record for Swaine L. Chen

Herman F. Staats

2Department of Pathology, Duke University, Durham, NC 27710, USA.

8Department of Immunology, Duke University, Durham, NC 27710, USA.

9Department of Medicine, Duke University, Durham, NC 27710, USA.

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Soman N. Abraham

1Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

2Department of Pathology, Duke University, Durham, NC 27710, USA.

3Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.

8Department of Immunology, Duke University, Durham, NC 27710, USA.

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For correspondence: soman.abraham@duke.edu

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MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

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