MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

Mohammad Arifuzzaman; Yuvon R. Mobley; Hae Woong Choi; Pradeep Bist; Cristina A. Salinas; Zachary D. Brown; Swaine L. Chen; Herman F. Staats; Soman N. Abraham

doi:10.1126/sciadv.aav0216

Research ArticleIMMUNOLOGY

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

Mohammad Arifuzzaman¹,
Yuvon R. Mobley¹,*,
Hae Woong Choi²,
Pradeep Bist³,
Cristina A. Salinas⁴,
Zachary D. Brown⁵,
Swaine L. Chen⁶,⁷,
Herman F. Staats ²,⁸,⁹ and
Soman N. Abraham ¹,²,³,⁸,†

¹Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.
²Department of Pathology, Duke University, Durham, NC 27710, USA.
³Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.
⁴Undergraduate Program in Biology, Duke University, Durham, NC 27710, USA.
⁵Undergraduate Program in Biomedical Engineering, Duke University, Durham, NC 27710, USA.
⁶Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
⁷Infectious Diseases Group, Genome Institute of Singapore, Singapore 138672, Singapore.
⁸Department of Immunology, Duke University, Durham, NC 27710, USA.
⁹Department of Medicine, Duke University, Durham, NC 27710, USA.

↵†Corresponding author. Email: soman.abraham{at}duke.edu

↵* Present address: Assurex Health, Mason, OH 45040, USA.

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Science Advances 02 Jan 2019:
Vol. 5, no. 1, eaav0216
DOI: 10.1126/sciadv.aav0216

Mohammad Arifuzzaman

Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

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Yuvon R. Mobley

Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

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Hae Woong Choi

Department of Pathology, Duke University, Durham, NC 27710, USA.

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Pradeep Bist

Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.

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Cristina A. Salinas

Undergraduate Program in Biology, Duke University, Durham, NC 27710, USA.

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Zachary D. Brown

Undergraduate Program in Biomedical Engineering, Duke University, Durham, NC 27710, USA.

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Swaine L. Chen

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

Infectious Diseases Group, Genome Institute of Singapore, Singapore 138672, Singapore.

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ORCID record for Swaine L. Chen

Herman F. Staats

Department of Pathology, Duke University, Durham, NC 27710, USA.

Department of Immunology, Duke University, Durham, NC 27710, USA.

Department of Medicine, Duke University, Durham, NC 27710, USA.

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Soman N. Abraham

Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

Department of Pathology, Duke University, Durham, NC 27710, USA.

Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.

Department of Immunology, Duke University, Durham, NC 27710, USA.

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For correspondence: soman.abraham@duke.edu

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MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

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