Research ArticleVIROLOGY

Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

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Science Advances  02 Jan 2019:
Vol. 5, no. 1, eaav1882
DOI: 10.1126/sciadv.aav1882

Article Information

vol. 5 no. 1

Online ISSN: 
History: 
  • Received for publication August 22, 2018
  • Accepted for publication November 27, 2018
  • .

Author Information

  1. Netanel Tzarum1,
  2. Erick Giang2,
  3. Leopold Kong1,
  4. Linling He2,
  5. Jannick Prentoe3,
  6. Elias Augestad3,
  7. Yuanzi Hua1,
  8. Shaun Castillo2,
  9. Georg M. Lauer4,
  10. Jens Bukh3,
  11. Jiang Zhu1,2,*,
  12. Ian A. Wilson1,5,* and
  13. Mansun Law2,*
  1. 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  2. 2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  3. 3Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  4. 4Gastrointestinal Unit and Liver Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  5. 5Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  1. *Corresponding author. Email: mlaw{at}scripps.edu (M.L.); wilson{at}scripps.edu (I.A.W.); jiang{at}scripps.edu (J.Z.)

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