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BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential

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Science Advances  23 Oct 2019:
Vol. 5, no. 10, eaaw3113
DOI: 10.1126/sciadv.aaw3113

Article Information

vol. 5 no. 10

Online ISSN: 
  • Received for publication December 7, 2018
  • Accepted for publication September 13, 2019
  • .

Author Information

  1. S. Miah1,2,
  2. C. A. S. Banks1,
  3. Y. Ogunbolude2,
  4. E. T. Bagu2,*,
  5. J. M. Berg2,
  6. A. Saraf1,
  7. T. T. Tettey1,
  8. G. Hattem1,
  9. G. Dayebgadoh1,
  10. C. G. Kempf1,
  11. M. Sardiu1,
  12. S. Napper2,3,
  13. L. Florens1,
  14. K. E. Lukong2, and
  15. M. P. Washburn1,4,
  1. 1Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
  2. 2Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
  3. 3Vaccine and Infectious Disease Organization–International Vaccine Centre, University of Saskatchewan, Saskatoon, SK S7 N 5E3, Canada.
  4. 4Departments of Pathology and Laboratory Medicine, University of Kansas Medical Centre, Kansas City, KS 66160, USA.
  1. Corresponding authors. Email: kiven.lukong{at} (K.E.L.); mpw{at} (M.P.W.)
  • * Present address: Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA.


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