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Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import

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Science Advances  09 Oct 2019:
Vol. 5, no. 10, eaaw7373
DOI: 10.1126/sciadv.aaw7373

Article Information

vol. 5 no. 10

Online ISSN: 
History: 
  • Received for publication January 20, 2019
  • Accepted for publication September 14, 2019
  • .

Author Information

  1. Junhua Li1,*,
  2. Jun Zhao1,
  3. Simin Xu1,
  4. Shu Zhang1,
  5. Junjie Zhang1,
  6. Jun Xiao1,2,
  7. Ruoyun Gao1,
  8. Mao Tian1,
  9. Yi Zeng1,3,
  10. Katie Lee1,
  11. Vera Tarakanova4,
  12. Ke Lan5,
  13. Hao Feng2 and
  14. Pinghui Feng1,
  1. 1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
  2. 2Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  3. 3Department of Pathology and Immunology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China.
  4. 4Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  5. 5State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei 430072, P.R. China.
  1. Corresponding author. Email: pinghui.feng{at}usc.edu
  • * Present address: State Key Laboratory of Agricultural Microbiology, College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China.

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