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Research ArticleBIOCHEMISTRY
Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import
- View ORCID ProfileJunhua Li1,*,
- Jun Zhao1,
- View ORCID ProfileSimin Xu1,
- View ORCID ProfileShu Zhang1,
- View ORCID ProfileJunjie Zhang1,
- Jun Xiao1,2,
- Ruoyun Gao1,
- Mao Tian1,
- Yi Zeng1,3,
- Katie Lee1,
- Vera Tarakanova4,
- View ORCID ProfileKe Lan5,
- Hao Feng2 and
- View ORCID ProfilePinghui Feng1,†
- 1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
- 2Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
- 3Department of Pathology and Immunology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China.
- 4Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
- 5State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei 430072, P.R. China.
- ↵†Corresponding author. Email: pinghui.feng{at}usc.edu
↵* Present address: State Key Laboratory of Agricultural Microbiology, College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China.
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Science Advances 09 Oct 2019:
Vol. 5, no. 10, eaaw7373
DOI: 10.1126/sciadv.aaw7373
Vol. 5, no. 10, eaaw7373
DOI: 10.1126/sciadv.aaw7373
Junhua Li
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
Jun Zhao
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
Simin Xu
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
Shu Zhang
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
Junjie Zhang
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
Jun Xiao
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
2Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
Ruoyun Gao
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
Mao Tian
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
Yi Zeng
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
3Department of Pathology and Immunology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China.
Katie Lee
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
Vera Tarakanova
4Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Ke Lan
5State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei 430072, P.R. China.
Hao Feng
2Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
Pinghui Feng
1Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.
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