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PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer

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Science Advances  16 Oct 2019:
Vol. 5, no. 10, eaaw8417
DOI: 10.1126/sciadv.aaw8417

Article Information

vol. 5 no. 10

Online ISSN: 
History: 
  • Received for publication January 29, 2019
  • Accepted for publication September 19, 2019
  • .

Author Information

  1. Qun Li1,2,3,*,
  2. Qiongyu Hao4,*,
  3. Wei Cao4,
  4. Jieqing Li4,
  5. Ke Wu4,
  6. Yahya Elshimali4,
  7. Donghui Zhu5,
  8. Qiao-Hong Chen6,
  9. Guanglin Chen6,
  10. Jonathan R. Pollack3,
  11. Jay Vadgama4,, and
  12. Yong Wu4,,
  1. 1Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
  2. 2Department of Oncology, Shanghai Cancer Center and Shanghai Medical College, Fudan University, Shanghai 200032, China.
  3. 3Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  4. 4Division of Cancer Research and Training, Department of Internal Medicine, Charles Drew University of Medicine and Science, David Geffen UCLA School of Medicine and UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA 90059, USA.
  5. 5University of North Texas, Denton, TX 76203, USA.
  6. 6Department of Chemistry, California State University, Fresno, 2555 E. San Ramon Avenue, M/S SB70, Fresno, CA 93740, USA.
  1. Corresponding author. Email: jayvadgama{at}cdrewu.edu (J.V.); yongwu{at}cdrewu.edu (Y.W.)
  • * These authors contributed equally to this work as first authors.

  • These authors contributed equally to this work as last authors.

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