Research ArticleIMMUNOLOGY

Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1

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Science Advances  09 Oct 2019:
Vol. 5, no. 10, eaax1608
DOI: 10.1126/sciadv.aax1608

Article Information

vol. 5 no. 10

Online ISSN: 
  • Received for publication February 27, 2019
  • Accepted for publication September 14, 2019
  • .

Author Information

  1. Feng Lin1,2,*,
  2. Xiaoyu Meng1,2,*,
  3. Yixin Guo1,2,
  4. Wenqiang Cao1,2,,
  5. Wanlu Liu3,
  6. Qiming Xia1,2,
  7. Zhaoyuan Hui1,2,
  8. Jian Chen4,
  9. Shenghui Hong5,
  10. Xuliang Zhang5,
  11. Chuan Wu6,
  12. Di Wang7,
  13. Jianli Wang1,2,
  14. Linrong Lu7,
  15. Wenbin Qian2,
  16. Lai Wei8 and
  17. Lie Wang1,2,5,
  1. 1Institute of Immunology and Bone Marrow Transplantation Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  2. 2Institute of Hematology, Zhejiang University and Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou, China.
  3. 3Zhejiang University–University of Edinburgh Joint Institute, Zhejiang University, Haining, China.
  4. 4Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  5. 5Laboratory Animal Center, Zhejiang University, Hangzhou, China.
  6. 6Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  7. 7Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China.
  8. 8State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
  1. Corresponding author. Email: wanglie{at}
  • * These authors contributed equally to this work.

  • Present address: Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.


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