Research ArticleSTRUCTURAL BIOLOGY

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

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Science Advances  09 Oct 2019:
Vol. 5, no. 10, eaax2518
DOI: 10.1126/sciadv.aax2518

Article Information

vol. 5 no. 10

Online ISSN: 
History: 
  • Received for publication March 8, 2019
  • Accepted for publication September 18, 2019
  • .

Author Information

  1. Aleksandra Luginina1,*,
  2. Anastasiia Gusach1,*,
  3. Egor Marin1,
  4. Alexey Mishin1,
  5. Rebecca Brouillette2,
  6. Petr Popov1,,
  7. Anna Shiriaeva3,
  8. Élie Besserer-Offroy2,
  9. Jean-Michel Longpré2,
  10. Elizaveta Lyapina1,
  11. Andrii Ishchenko3,,
  12. Nilkanth Patel3,
  13. Vitaly Polovinkin4,5,6,
  14. Nadezhda Safronova1,
  15. Andrey Bogorodskiy1,
  16. Evelina Edelweiss5,
  17. Hao Hu7,8,
  18. Uwe Weierstall7,8,
  19. Wei Liu8,9,
  20. Alexander Batyuk10,
  21. Valentin Gordeliy1,4,5,11,12,
  22. Gye Won Han3,
  23. Philippe Sarret2,
  24. Vsevolod Katritch3,§,
  25. Valentin Borshchevskiy1,4,11,§ and
  26. Vadim Cherezov1,3,§,||
  1. 1Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
  2. 2Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.
  3. 3Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
  4. 4Institute of Complex Systems, ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.
  5. 5Institut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes-CEA-CNRS, Grenoble 38000, France.
  6. 6ELI Beamlines, Institute of Physics, Czech Academy of Sciences, 18221 Prague, Czech Republic.
  7. 7Department of Physics, Arizona State University, Tempe, AZ 85287, USA.
  8. 8Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
  9. 9School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
  10. 10Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
  11. 11Juelich Center for Structural Biology, Research Center Juelich, Juelich, Germany.
  12. 12Institute of Crystallography, RWTH Aachen University, Aachen, Germany.
  1. §Corresponding author. Email: cherezov@usc.edu (V.C.); borshchevskiy.vi@mipt.ru (V.B.); katritch@usc.edu (V.K.)
  • * These authors contributed equally to this work.

  • Present address: Center for Computational and Data Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, Building 1, Moscow 121205, Russia.

  • Present address: Merck Research Laboratories, Merck & Co Inc., 770 Sumneytown Pike, West Point, PA 19486, USA.

  • || Lead contact.

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