Research ArticleCELL BIOLOGY

Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development

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Science Advances  16 Oct 2019:
Vol. 5, no. 10, eaax4199
DOI: 10.1126/sciadv.aax4199

Article Information

vol. 5 no. 10

Online ISSN: 
History: 
  • Received for publication March 22, 2019
  • Accepted for publication September 22, 2019
  • .

Author Information

  1. João Frade1,2,*,
  2. Shoma Nakagawa1,,
  3. Paola Cortes1,,
  4. Umberto di Vicino1,,
  5. Neus Romo1,
  6. Frederic Lluis2, and
  7. Maria Pia Cosma1,3,4,5,6
  1. 1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.
  2. 2Stem Cell Institute Leuven (SCIL), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
  3. 3Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
  4. 4ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain.
  5. 5Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou 510005, China.
  6. 6Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510530, China.
  1. Corresponding author. Email: frederic.lluisvinas{at}kuleuven.be
  • * Present address: Institute for Molecular Biotechnology (IMBA), Dr. Bohr-Gasse 3, 1030 Vienna, Austria.

  • These authors contributed equally to this work.

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