More than efficacy revealed by single-cell analysis of antiviral therapeutics

Wu Liu; Mehmet U. Caglar; Zhangming Mao; Andrew Woodman; Jamie J. Arnold; Claus O. Wilke; Craig E. Cameron

doi:10.1126/sciadv.aax4761

Research ArticleVIROLOGY

More than efficacy revealed by single-cell analysis of antiviral therapeutics

View ORCID ProfileWu Liu¹,*,†,
View ORCID ProfileMehmet U. Caglar²,
Zhangming Mao³,
Andrew Woodman ¹,
Jamie J. Arnold¹,
View ORCID ProfileClaus O. Wilke ² and
View ORCID ProfileCraig E. Cameron ¹,*,‡

¹Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA.
²Center for Computational Biology and Bioinformatics, Institute for Cellular and Molecular Biology, and Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA.
³Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.

↵*Corresponding author. Email: wuliu{at}andrew.cmu.edu (W.L.); craig.cameron{at}med.unc.edu (C.E.C.)

↵† Present address: Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
↵‡ Present address: Department of Microbiology and Immunology, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.

See allHide authors and affiliations

Science Advances 30 Oct 2019:
Vol. 5, no. 10, eaax4761
DOI: 10.1126/sciadv.aax4761

Wu Liu

1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Wu Liu
For correspondence: wuliu@andrew.cmu.edu craig.cameron@med.unc.edu

Mehmet U. Caglar

2Center for Computational Biology and Bioinformatics, Institute for Cellular and Molecular Biology, and Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Mehmet U. Caglar

Zhangming Mao

3Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andrew Woodman

1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jamie J. Arnold

1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Claus O. Wilke

2Center for Computational Biology and Bioinformatics, Institute for Cellular and Molecular Biology, and Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Claus O. Wilke

Craig E. Cameron

1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Craig E. Cameron
For correspondence: wuliu@andrew.cmu.edu craig.cameron@med.unc.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all . Please read our guidelines before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

More than efficacy revealed by single-cell analysis of antiviral therapeutics

Plain text

Vertical Tabs

Science Advances

Article Tools