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Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

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Science Advances  16 Oct 2019:
Vol. 5, no. 10, eaax5108
DOI: 10.1126/sciadv.aax5108

Article Information

vol. 5 no. 10

Online ISSN: 
History: 
  • Received for publication March 30, 2019
  • Accepted for publication September 25, 2019
  • .

Author Information

  1. Dafni C. Delivoria1,2,
  2. Sean Chia3,
  3. Johnny Habchi3,
  4. Michele Perni3,
  5. Ilias Matis1,
  6. Nikoletta Papaevgeniou1,4,
  7. Martin Reczko5,
  8. Niki Chondrogianni1,
  9. Christopher M. Dobson3,
  10. Michele Vendruscolo3 and
  11. Georgios Skretas1,*
  1. 1Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
  2. 2School of Chemical Engineering, National Technical University of Athens, Athens 15780, Greece.
  3. 3Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
  4. 4Faculty of Biology and Pharmacy, Institute of Nutrition, Friedrich Schiller University of Jena, Jena 07743, Germany.
  5. 5Institute for Fundamental Biomedical Science, Biomedical Sciences Research Center “Alexander Fleming,” Athens 16672, Greece.
  1. *Corresponding author. Email: gskretas{at}eie.gr

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