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Research ArticleDISEASES AND DISORDERS
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation
- View ORCID ProfileDafni C. Delivoria1,2,
- Sean Chia3,
- View ORCID ProfileJohnny Habchi3,
- View ORCID ProfileMichele Perni3,
- View ORCID ProfileIlias Matis1,
- Nikoletta Papaevgeniou1,4,
- View ORCID ProfileMartin Reczko5,
- Niki Chondrogianni1,
- View ORCID ProfileChristopher M. Dobson3,
- View ORCID ProfileMichele Vendruscolo3 and
- View ORCID ProfileGeorgios Skretas1,*
- 1Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
- 2School of Chemical Engineering, National Technical University of Athens, Athens 15780, Greece.
- 3Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
- 4Faculty of Biology and Pharmacy, Institute of Nutrition, Friedrich Schiller University of Jena, Jena 07743, Germany.
- 5Institute for Fundamental Biomedical Science, Biomedical Sciences Research Center “Alexander Fleming,” Athens 16672, Greece.
- ↵*Corresponding author. Email: gskretas{at}eie.gr
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Science Advances 16 Oct 2019:
Vol. 5, no. 10, eaax5108
DOI: 10.1126/sciadv.aax5108
Vol. 5, no. 10, eaax5108
DOI: 10.1126/sciadv.aax5108
Dafni C. Delivoria
1Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
2School of Chemical Engineering, National Technical University of Athens, Athens 15780, Greece.
Sean Chia
3Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Johnny Habchi
3Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Michele Perni
3Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Ilias Matis
1Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
Nikoletta Papaevgeniou
1Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
4Faculty of Biology and Pharmacy, Institute of Nutrition, Friedrich Schiller University of Jena, Jena 07743, Germany.
Martin Reczko
5Institute for Fundamental Biomedical Science, Biomedical Sciences Research Center “Alexander Fleming,” Athens 16672, Greece.
Niki Chondrogianni
1Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
Christopher M. Dobson
3Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Michele Vendruscolo
3Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Georgios Skretas
1Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
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