Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

Jennifer N. Cash; Sarah Urata; Sheng Li; Sandeep K. Ravala; Larisa V. Avramova; Michael D. Shost; J. Silvio Gutkind; John J. G. Tesmer; Michael A. Cianfrocco

doi:10.1126/sciadv.aax8855

Research ArticleSTRUCTURAL BIOLOGY

Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

View ORCID ProfileJennifer N. Cash¹,
View ORCID ProfileSarah Urata²,
View ORCID ProfileSheng Li²,
Sandeep K. Ravala³,
Larisa V. Avramova³,
View ORCID ProfileMichael D. Shost¹,
View ORCID ProfileJ. Silvio Gutkind⁴,
View ORCID ProfileJohn J. G. Tesmer ³,* and
View ORCID ProfileMichael A. Cianfrocco¹,*

¹Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
²Department of Medicine, University of California, San Diego, San Diego, CA, USA.
³Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
⁴Department of Pharmacology and Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.

↵*Corresponding author. Email: jtesmer{at}purdue.edu (J.J.G.T.); mcianfro{at}umich.edu (M.A.C.)

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Science Advances 16 Oct 2019:
Vol. 5, no. 10, eaax8855
DOI: 10.1126/sciadv.aax8855

Jennifer N. Cash

1Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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Sarah Urata

2Department of Medicine, University of California, San Diego, San Diego, CA, USA.

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Sheng Li

2Department of Medicine, University of California, San Diego, San Diego, CA, USA.

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Sandeep K. Ravala

3Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.

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Larisa V. Avramova

3Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.

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Michael D. Shost

1Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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J. Silvio Gutkind

4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.

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John J. G. Tesmer

3Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.

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For correspondence: jtesmer@purdue.edu mcianfro@umich.edu

Michael A. Cianfrocco

1Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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For correspondence: jtesmer@purdue.edu mcianfro@umich.edu

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Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

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