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Research ArticleSTRUCTURAL BIOLOGY
Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold
- View ORCID ProfileJennifer N. Cash1,
- View ORCID ProfileSarah Urata2,
- View ORCID ProfileSheng Li2,
- Sandeep K. Ravala3,
- Larisa V. Avramova3,
- View ORCID ProfileMichael D. Shost1,
- View ORCID ProfileJ. Silvio Gutkind4,
- View ORCID ProfileJohn J. G. Tesmer3,* and
- View ORCID ProfileMichael A. Cianfrocco1,*
- 1Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
- 2Department of Medicine, University of California, San Diego, San Diego, CA, USA.
- 3Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
- 4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.
- ↵*Corresponding author. Email: jtesmer{at}purdue.edu (J.J.G.T.); mcianfro{at}umich.edu (M.A.C.)
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Science Advances 16 Oct 2019:
Vol. 5, no. 10, eaax8855
DOI: 10.1126/sciadv.aax8855
Vol. 5, no. 10, eaax8855
DOI: 10.1126/sciadv.aax8855
Jennifer N. Cash
1Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Sarah Urata
2Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Sheng Li
2Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Sandeep K. Ravala
3Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Larisa V. Avramova
3Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Michael D. Shost
1Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
J. Silvio Gutkind
4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.
John J. G. Tesmer
3Departments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Michael A. Cianfrocco
1Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
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