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Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

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Science Advances  30 Oct 2019:
Vol. 5, no. 10, eaax9183
DOI: 10.1126/sciadv.aax9183

Article Information

vol. 5 no. 10

Online ISSN: 
  • Received for publication May 10, 2019
  • Accepted for publication September 14, 2019
  • .

Author Information

  1. Jessica M. Johnston1,
  2. Adrienn Angyal1,
  3. Robert C. Bauer2,3,
  4. Stephen Hamby4,
  5. S. Kim Suvarna1,
  6. Kajus Baidžajevas1,
  7. Zoltan Hegedus5,6,
  8. T. Neil Dear7,
  9. Martin Turner8,
  10. The Cardiogenics Consortium*,
  11. Heather L. Wilson1,
  12. Alison H. Goodall4,
  13. Daniel J. Rader3,
  14. Carol C. Shoulders9,,
  15. Sheila E. Francis1 and
  16. Endre Kiss-Toth1,
  1. 1Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK.
  2. 2Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  3. 3Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia, Philadelphia, PA 19104-5158, USA.
  4. 4Department of Cardiovascular Sciences, University of Leicester and NIHR Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
  5. 5Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, Temesvari korut 62, Szeged H-6726, Hungary.
  6. 6Departments of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Szigeti ut 12, Pecs H-7624, Hungary.
  7. 7Division of Biomedical Services, University of Leicester, Leicester, UK.
  8. 8Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
  9. 9Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London and the Barts and the London School of Medicine and Dentistry, London EC1M 6BQ, UK.
  1. Corresponding author. Email: c.shoulders{at} (C.C.S.); e.kiss-toth{at} (E.K.-T.)
  • * Membership of the Cardiogenics Consortium appears in the Supplementary Materials.


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