Research ArticleMATERIALS SCIENCE

Integrated textile sensor patch for real-time and multiplex sweat analysis

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Science Advances  08 Nov 2019:
Vol. 5, no. 11, eaax0649
DOI: 10.1126/sciadv.aax0649
  • Fig. 1 Wearable sweat analysis patch based on SilkNCT.

    (A and B) Schematic illustration of wearable sweat analysis patch mounted on human skin (A) and the multiplex electrochemical sensor array integrated in the patch (B). (C) Photograph of the wearable sweat analysis patch. (D and E) SEM (D) and TEM (E) images of the carbonized silk fabric, showing its hierarchical woven macrostructure and microcrystalline graphite-like microstructure, respectively. (F) High-resolution XPS spectrum of N1s for the carbonized silk fabric. a.u., arbitrary units. (G) EIS of the carbonized silk fabric prepared at different temperatures. Inset in (G) shows an equivalent circuit model. (H) Cyclic voltammograms of the carbonized silk fabric prepared at different temperatures in 0.1 M KCl solution containing 5.0 mM [Fe(CN)6]3−/4−. Photo credit: Wenya He, Tsinghua University.

  • Fig. 2 Performance of the flexible SilkNCT-based sensors for multiple biomarkers.

    (A) Chronoamperometry responses of the SilkNCT-based glucose sensor. (B) DPV responses of the SilkNCT-based AA sensor to the AA solution in phosphate-buffered saline (PBS). (C) OCP responses of the SilkNCT-based Na+ sensor. Insets in (A) to (C) show the corresponding calibration plots of the sensors. The error bars represent the SDs of the measured data with five points. (D to F) Reproducibility of the SilkNCT-based glucose sensors (D), AA sensors (E), and Na+ sensors (F). (G to I) Selectivity of the SilkNCT-based glucose sensors (G), AA sensors (H), and Na+ sensors (I).

  • Fig. 3 Flexibility and stability of the SilkNCT-based flexible electrochemical sensors.

    (A to C) Photographs of the as-prepared SilkNCT-based flexible sensor array. (D to F) Electrochemical responses of the SilkNCT-based glucose sensors (D), AA sensors (E), and Na+ sensors (F) after different bending cycles. Data recording was paused for bending cycles in (D) to (F). (G to I) Electrochemical responses of the SilkNCT-based glucose sensors (G), AA sensors (H), and Na+ sensors (I) after different storage time. The error bars represent the SDs of the measured data from five samples. Photo credit: Wenya He, Tsinghua University.

  • Fig. 4 The integrated sweat analysis patch and its application for real-time and wireless sweat analysis.

    (A) Photograph and illustration of the integrated sweat analysis patch composed of six sensors, signal collection/transduction/conditioning/processing, and wireless transmission components. (B) Photograph showing the sweat analysis patch mounted on the arm of a volunteer (in physical activity) for in situ monitoring of the biomarkers in his sweat. (C) Comparison of the glucose concentrations detected by the sweat analysis patch and HPLC-MS. Photo credit: Wenya He, Tsinghua University.

Supplementary Materials

  • Supplementary material for this article is available at http://advances.sciencemag.org/cgi/content/full/5/11/eaax0649/DC1

    Fig. S1. Schematic illustration of the fabrication process of the flexible multiple electrochemical sensor array.

    Fig. S2. Hydrophilic characterization of carbonized silk fabric.

    Fig. S3. XPS survey spectrum and C1s peak of carbonized silk fabric.

    Fig. S4. I-V curves of carbonized silk fabric obtained at different temperatures.

    Fig. S5. High-resolution XPS spectra of N1s for SilkNCT obtained at different temperatures.

    Fig. S6. DPV responses of SilkNCT and C-cotton–based AA sensors to AA.

    Fig. S7. Schematic diagram showing the working mechanisms of each sensor.

    Fig. S8. SEM images of modified electrode for enzyme-based sensors.

    Fig. S9. SEM images of modified electrode for ion-selective sensors.

    Fig. S10. Sensing performance of the flexible SilkNCT-based electrochemical sensors for multiple biomarkers.

    Fig. S11. Photographs of a sensing patch fabricated on a common silk fabric.

    Fig. S12. Flexibility and stability of the SilkNCT-based flexible electrochemcial sensors.

    Table S1. Atomic composition of pristine and carbonized silk fabric (obtained at 900°C).

    Table S2. Gross content of N and relative content of various N species in SilkNCT samples obtained at different temperatures.

    Table S3. Comparison of the sensitivity for various biomarkers of the recently reported wearable electrochemical sensors for sweat analysis with this work.

    References (4148)

  • Supplementary Materials

    This PDF file includes:

    • Fig. S1. Schematic illustration of the fabrication process of the flexible multiple electrochemical sensor array.
    • Fig. S2. Hydrophilic characterization of carbonized silk fabric.
    • Fig. S3. XPS survey spectrum and C1s peak of carbonized silk fabric.
    • Fig. S4. I-V curves of carbonized silk fabric obtained at different temperatures.
    • Fig. S5. High-resolution XPS spectra of N1s for SilkNCT obtained at different temperatures.
    • Fig. S6. DPV responses of SilkNCT and C-cotton–based AA sensors to AA.
    • Fig. S7. Schematic diagram showing the working mechanisms of each sensor.
    • Fig. S8. SEM images of modified electrode for enzyme-based sensors.
    • Fig. S9. SEM images of modified electrode for ion-selective sensors.
    • Fig. S10. Sensing performance of the flexible SilkNCT-based electrochemical sensors for multiple biomarkers.
    • Fig. S11. Photographs of a sensing patch fabricated on a common silk fabric.
    • Fig. S12. Flexibility and stability of the SilkNCT-based flexible electrochemcial sensors.
    • Table S1. Atomic composition of pristine and carbonized silk fabric (obtained at 900°C).
    • Table S2. Gross content of N and relative content of various N species in SilkNCT samples obtained at different temperatures.
    • Table S3. Comparison of the sensitivity for various biomarkers of the recently reported wearable electrochemical sensors for sweat analysis with this work.
    • References (4148)

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