In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids

Yesl Jun; JaeSeo Lee; Seongkyun Choi; Ji Hun Yang; Maike Sander; Seok Chung; Sang-Hoon Lee

doi:10.1126/sciadv.aax4520

Research ArticleCELL BIOLOGY

In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids

View ORCID ProfileYesl Jun ¹,²,
View ORCID ProfileJaeSeo Lee³,
View ORCID ProfileSeongkyun Choi ²,
View ORCID ProfileJi Hun Yang ²,⁴,
Maike Sander ¹,*,
View ORCID ProfileSeok Chung ²,³,* and
Sang-Hoon Lee³,⁵

¹Departments of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA.
²School of Mechanical Engineering, Korea University, Seoul 02841, Republic of Korea.
³KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.
⁴Next & Bio Inc., Seoul National University, Seoul 08826, Republic of Korea.
⁵School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea.

↵*Corresponding author. Email: sidchung{at}korea.ac.kr (S.C.); masander{at}ucsd.edu (M.S.)

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Science Advances 27 Nov 2019:
Vol. 5, no. 11, eaax4520
DOI: 10.1126/sciadv.aax4520

Yesl Jun

1Departments of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA.

2School of Mechanical Engineering, Korea University, Seoul 02841, Republic of Korea.

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JaeSeo Lee

3KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.

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Seongkyun Choi

2School of Mechanical Engineering, Korea University, Seoul 02841, Republic of Korea.

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Ji Hun Yang

2School of Mechanical Engineering, Korea University, Seoul 02841, Republic of Korea.

4Next & Bio Inc., Seoul National University, Seoul 08826, Republic of Korea.

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Maike Sander

1Departments of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA.

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For correspondence: sidchung@korea.ac.kr masander@ucsd.edu

Seok Chung

2School of Mechanical Engineering, Korea University, Seoul 02841, Republic of Korea.

3KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.

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For correspondence: sidchung@korea.ac.kr masander@ucsd.edu

Sang-Hoon Lee

3KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.

5School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea.

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