Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

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Science Advances  27 Nov 2019:
Vol. 5, no. 11, eaax9115
DOI: 10.1126/sciadv.aax9115

Article Information

vol. 5 no. 11

Online ISSN: 
  • Received for publication May 3, 2019
  • Accepted for publication September 25, 2019
  • .

Author Information

  1. Tobias Claff1,2,*,
  2. Jing Yu1,3,4,5,*,
  3. Véronique Blais6,
  4. Nilkanth Patel7,
  5. Charlotte Martin8,
  6. Lijie Wu1,
  7. Gye Won Han7,
  8. Brian J. Holleran6,
  9. Olivier Van der Poorten8,
  10. Kate L. White7,
  11. Michael A. Hanson9,
  12. Philippe Sarret6,
  13. Louis Gendron6,
  14. Vadim Cherezov7,
  15. Vsevolod Katritch7,
  16. Steven Ballet8,
  17. Zhi-Jie Liu1,3,
  18. Christa E. Müller2, and
  19. Raymond C. Stevens1,7,
  1. 1iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Rd, Pudong, Shanghai 201210, China.
  2. 2PharmaCenter Bonn, University of Bonn, Pharmaceutical Chemistry I, An der Immenburg 4, D-53121 Bonn, Germany.
  3. 3School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  4. 4CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
  5. 5University of the Chinese Academy of Sciences, Beijing 100049, China.
  6. 6Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du CHUS, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada.
  7. 7Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
  8. 8Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
  9. 9GPCR Consortium, San Marcos, CA 92078, USA.
  1. Corresponding author. Email: christa.mueller{at} (C.E.M.); stevens{at} (R.C.S.)
  • * These authors contributed equally to this work.


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