Requirement for translocon-associated protein (TRAP) α in insulin biogenesis

Xin Li; Omar A. Itani; Leena Haataja; Kathleen J. Dumas; Jing Yang; Jeeyeon Cha; Stephane Flibotte; Hung-Jen Shih; Colin E. Delaney; Jialu Xu; Ling Qi; Peter Arvan; Ming Liu; Patrick J. Hu

doi:10.1126/sciadv.aax0292

Research ArticleCELL BIOLOGY

Requirement for translocon-associated protein (TRAP) α in insulin biogenesis

View ORCID ProfileXin Li¹,²,*,
View ORCID ProfileOmar A. Itani ²,³,*,
Leena Haataja²,⁴,
View ORCID ProfileKathleen J. Dumas²,³,
Jing Yang¹,
Jeeyeon Cha ⁵,⁶,
Stephane Flibotte⁷,
Hung-Jen Shih³,
View ORCID ProfileColin E. Delaney³,
Jialu Xu¹,
View ORCID ProfileLing Qi ²,⁴,
Peter Arvan ²,⁴,
View ORCID ProfileMing Liu ¹,²,⁴,† and
View ORCID ProfilePatrick J. Hu ²,³,⁵,⁸,⁹,†

¹Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
²Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
³Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
⁴Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.
⁵Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
⁶Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA.
⁷Departments of Zoology and Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
⁸Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁹Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.

↵†Corresponding author. Email: patrick.j.hu{at}vumc.org (P.J.H.); mingli{at}med.umich.edu (M.L.)

↵* These authors contributed equally to this work.

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Science Advances 04 Dec 2019:
Vol. 5, no. 12, eaax0292
DOI: 10.1126/sciadv.aax0292

Xin Li

1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

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Omar A. Itani

2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

3Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

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Leena Haataja

2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

4Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.

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Kathleen J. Dumas

2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

3Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

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Jing Yang

1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

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Jeeyeon Cha

5Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

6Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA.

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Stephane Flibotte

7Departments of Zoology and Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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Hung-Jen Shih

3Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

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Colin E. Delaney

3Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

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Jialu Xu

1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

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Ling Qi

2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

4Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.

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Peter Arvan

2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

4Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.

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Ming Liu

1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

4Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.

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For correspondence: patrick.j.hu@vumc.org mingli@med.umich.edu

Patrick J. Hu

2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

3Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

5Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

8Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA.

9Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.

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ORCID record for Patrick J. Hu
For correspondence: patrick.j.hu@vumc.org mingli@med.umich.edu

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