Research ArticleNEUROPHYSIOLOGY

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

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Science Advances  18 Dec 2019:
Vol. 5, no. 12, eaay2670
DOI: 10.1126/sciadv.aay2670

Article Information

vol. 5 no. 12

Online ISSN: 
History: 
  • Received for publication July 5, 2019
  • Accepted for publication October 23, 2019
  • .

Author Information

  1. S. Keihani1,*,
  2. V. Kluever1,*,
  3. S. Mandad1,2,
  4. V. Bansal3,4,
  5. R. Rahman3,
  6. E. Fritsch1,
  7. L. Caldi Gomes5,6,
  8. A. Gärtner7,
  9. S. Kügler5,
  10. H. Urlaub2,8,
  11. J. D. Wren9,
  12. S. Bonn3,4,
  13. S. O. Rizzoli1,6 and
  14. E. F. Fornasiero1,6,
  1. 1Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.
  2. 2Department of Clinical Chemistry, University Medical Center Göttingen, 37077 Göttingen, Germany.
  3. 3Institute of Medical Systems Biology, Center for Molecular Neurobiology (ZMNH), UKE, 20246 Hamburg, Germany.
  4. 4German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
  5. 5Department of Neurology, University Medical Center Göttingen, 37073 Göttingen, Germany.
  6. 6Center for Biostructural Imaging of Neurodegeneration (BIN), 37075 Göttingen, Germany.
  7. 7VIB Center for the Biology of Disease and Center for Human Genetics, KU Leuven, Leuven, Belgium.
  8. 8Bioanalytical Mass Spectrometry Group, Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany.
  9. 9Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
  1. Corresponding author. Email: efornas{at}gwdg.de
  • * These authors contributed equally to this work as first authors.

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