Research ArticleNEUROPHYSIOLOGY
The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43
- View ORCID ProfileS. Keihani1,*,
- View ORCID ProfileV. Kluever1,*,
- S. Mandad1,2,
- View ORCID ProfileV. Bansal3,4,
- R. Rahman3,
- View ORCID ProfileE. Fritsch1,
- View ORCID ProfileL. Caldi Gomes5,6,
- View ORCID ProfileA. Gärtner7,
- S. Kügler5,
- H. Urlaub2,8,
- View ORCID ProfileJ. D. Wren9,
- View ORCID ProfileS. Bonn3,4,
- S. O. Rizzoli1,6 and
- View ORCID ProfileE. F. Fornasiero1,6,†
- 1Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.
- 2Department of Clinical Chemistry, University Medical Center Göttingen, 37077 Göttingen, Germany.
- 3Institute of Medical Systems Biology, Center for Molecular Neurobiology (ZMNH), UKE, 20246 Hamburg, Germany.
- 4German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
- 5Department of Neurology, University Medical Center Göttingen, 37073 Göttingen, Germany.
- 6Center for Biostructural Imaging of Neurodegeneration (BIN), 37075 Göttingen, Germany.
- 7VIB Center for the Biology of Disease and Center for Human Genetics, KU Leuven, Leuven, Belgium.
- 8Bioanalytical Mass Spectrometry Group, Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany.
- 9Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
- ↵†Corresponding author. Email: efornas{at}gwdg.de
↵* These authors contributed equally to this work as first authors.
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Science Advances 18 Dec 2019:
Vol. 5, no. 12, eaay2670
DOI: 10.1126/sciadv.aay2670
Vol. 5, no. 12, eaay2670
DOI: 10.1126/sciadv.aay2670
S. Keihani
1Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.
V. Kluever
1Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.
S. Mandad
1Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.
2Department of Clinical Chemistry, University Medical Center Göttingen, 37077 Göttingen, Germany.
V. Bansal
3Institute of Medical Systems Biology, Center for Molecular Neurobiology (ZMNH), UKE, 20246 Hamburg, Germany.
4German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
R. Rahman
3Institute of Medical Systems Biology, Center for Molecular Neurobiology (ZMNH), UKE, 20246 Hamburg, Germany.
E. Fritsch
1Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.
L. Caldi Gomes
5Department of Neurology, University Medical Center Göttingen, 37073 Göttingen, Germany.
6Center for Biostructural Imaging of Neurodegeneration (BIN), 37075 Göttingen, Germany.
A. Gärtner
7VIB Center for the Biology of Disease and Center for Human Genetics, KU Leuven, Leuven, Belgium.
S. Kügler
5Department of Neurology, University Medical Center Göttingen, 37073 Göttingen, Germany.
H. Urlaub
2Department of Clinical Chemistry, University Medical Center Göttingen, 37077 Göttingen, Germany.
8Bioanalytical Mass Spectrometry Group, Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany.
J. D. Wren
9Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
S. Bonn
3Institute of Medical Systems Biology, Center for Molecular Neurobiology (ZMNH), UKE, 20246 Hamburg, Germany.
4German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
S. O. Rizzoli
1Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.
6Center for Biostructural Imaging of Neurodegeneration (BIN), 37075 Göttingen, Germany.
E. F. Fornasiero
1Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.
6Center for Biostructural Imaging of Neurodegeneration (BIN), 37075 Göttingen, Germany.
