Research ArticleAPPLIED SCIENCES AND ENGINEERING

Carboxylated branched poly(β-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing

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Science Advances  06 Dec 2019:
Vol. 5, no. 12, eaay3255
DOI: 10.1126/sciadv.aay3255

Article Information

vol. 5 no. 12

Online ISSN: 
History: 
  • Received for publication June 8, 2019
  • Accepted for publication September 24, 2019
  • .

Author Information

  1. Yuan Rui1,
  2. David R. Wilson1,
  3. John Choi2,
  4. Mahita Varanasi1,
  5. Katie Sanders1,
  6. Johan Karlsson1,
  7. Michael Lim2,3 and
  8. Jordan J. Green1,2,3,4,*
  1. 1Department of Biomedical Engineering, Institute for NanoBioTechnology, and Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  2. 2Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  3. 3Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  4. 4Departments of Ophthalmology, Materials Science and Engineering, and Chemical and Biomolecular Engineering, and the Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  1. *Corresponding author. Email: green{at}jhu.edu

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