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The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

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Science Advances  06 Feb 2019:
Vol. 5, no. 2, eaau8317
DOI: 10.1126/sciadv.aau8317

Article Information

vol. 5 no. 2

Online ISSN: 
History: 
  • Received for publication July 20, 2018
  • Accepted for publication December 20, 2018
  • .

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Author Information

  1. Peng Zheng1,2,3,*,
  2. Benhua Zeng4,*,
  3. Meiling Liu5,
  4. Jianjun Chen6,
  5. Junxi Pan2,3,7,
  6. Yu Han1,2,3,
  7. Yiyun Liu1,2,3,
  8. Ke Cheng1,2,3,
  9. Chanjuan Zhou2,3,
  10. Haiyang Wang1,2,3,
  11. Xinyu Zhou1,2,3,
  12. Siwen Gui1,2,3,
  13. Seth W. Perry8,
  14. Ma-Li Wong8,
  15. Julio Licinio8,,,
  16. Hong Wei9,, and
  17. Peng Xie1,2,3,,
  1. 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  2. 2Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China.
  3. 3Chongqing Key Laboratory of Neurobiology, Chongqing, China.
  4. 4Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China.
  5. 5Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  6. 6College of Life Sciences, Chongqing Medical University, Chongqing, China.
  7. 7The M.O.E. Key Laboratory of Laboratory Medical Diagnostics, the College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
  8. 8Department of Psychiatry, College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
  9. 9Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
  1. Corresponding author. Email: xiepeng{at}cqmu.edu.cn (P.X.); weihong63528{at}163.com (H.W.); licinioj{at}upstate.edu (J.L.)
  • * These authors contributed equally to this work.

  • These authors are co-senior authors.

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