Influenza binds phosphorylated glycans from human lung

Lauren Byrd-Leotis; Nan Jia; Sucharita Dutta; Jessica F. Trost; Chao Gao; Sandra F. Cummings; Thomas Braulke; Sven Müller-Loennies; Jamie Heimburg-Molinaro; David A. Steinhauer; Richard D. Cummings

doi:10.1126/sciadv.aav2554

Research ArticleMICROBIOLOGY

Influenza binds phosphorylated glycans from human lung

View ORCID ProfileLauren Byrd-Leotis¹,²,*,
View ORCID ProfileNan Jia²,*,
Sucharita Dutta²,
View ORCID ProfileJessica F. Trost ¹,
View ORCID ProfileChao Gao²,
View ORCID ProfileSandra F. Cummings²,
View ORCID ProfileThomas Braulke³,
View ORCID ProfileSven Müller-Loennies⁴,
Jamie Heimburg-Molinaro²,
View ORCID ProfileDavid A. Steinhauer ¹,† and
View ORCID ProfileRichard D. Cummings ²,†

¹Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
²Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.
³Department of Biochemistry, Children’s Hospital, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.
⁴Research Center Borstel (RCB), Leibniz Lung Center, Division Biophysics, Parkallee 22, D-23845 Borstel, Germany.

↵†Corresponding author. Email: dsteinh{at}emory.edu (D.A.S.); rcummin1{at}bidmc.harvard.edu (R.D.C.)

↵* These authors contributed equally to this work as co-first authors.

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Science Advances 13 Feb 2019:
Vol. 5, no. 2, eaav2554
DOI: 10.1126/sciadv.aav2554

Lauren Byrd-Leotis

1Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

2Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Nan Jia

2Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Sucharita Dutta

2Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Jessica F. Trost

1Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

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Chao Gao

2Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Sandra F. Cummings

2Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Thomas Braulke

3Department of Biochemistry, Children’s Hospital, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

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Sven Müller-Loennies

4Research Center Borstel (RCB), Leibniz Lung Center, Division Biophysics, Parkallee 22, D-23845 Borstel, Germany.

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Jamie Heimburg-Molinaro

2Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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David A. Steinhauer

1Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

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For correspondence: dsteinh@emory.edu rcummin1@bidmc.harvard.edu

Richard D. Cummings

2Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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ORCID record for Richard D. Cummings
For correspondence: dsteinh@emory.edu rcummin1@bidmc.harvard.edu

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Influenza binds phosphorylated glycans from human lung

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