Influenza binds phosphorylated glycans from human lung

Lauren Byrd-Leotis; Nan Jia; Sucharita Dutta; Jessica F. Trost; Chao Gao; Sandra F. Cummings; Thomas Braulke; Sven Müller-Loennies; Jamie Heimburg-Molinaro; David A. Steinhauer; Richard D. Cummings

doi:10.1126/sciadv.aav2554

Research ArticleMICROBIOLOGY

Influenza binds phosphorylated glycans from human lung

Lauren Byrd-Leotis¹,²,*,
Nan Jia²,*,
Sucharita Dutta²,
Jessica F. Trost ¹,
Chao Gao²,
Sandra F. Cummings²,
Thomas Braulke³,
Sven Müller-Loennies⁴,
Jamie Heimburg-Molinaro²,
David A. Steinhauer ¹,† and
Richard D. Cummings ²,†

¹Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
²Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.
³Department of Biochemistry, Children’s Hospital, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.
⁴Research Center Borstel (RCB), Leibniz Lung Center, Division Biophysics, Parkallee 22, D-23845 Borstel, Germany.

↵†Corresponding author. Email: dsteinh{at}emory.edu (D.A.S.); rcummin1{at}bidmc.harvard.edu (R.D.C.)

↵* These authors contributed equally to this work as co-first authors.

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Science Advances 13 Feb 2019:
Vol. 5, no. 2, eaav2554
DOI: 10.1126/sciadv.aav2554

Lauren Byrd-Leotis

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Nan Jia

Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Sucharita Dutta

Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Jessica F. Trost

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

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Chao Gao

Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Sandra F. Cummings

Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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Thomas Braulke

Department of Biochemistry, Children’s Hospital, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

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Sven Müller-Loennies

Research Center Borstel (RCB), Leibniz Lung Center, Division Biophysics, Parkallee 22, D-23845 Borstel, Germany.

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Jamie Heimburg-Molinaro

Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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David A. Steinhauer

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

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For correspondence: dsteinh@emory.edu rcummin1@bidmc.harvard.edu

Richard D. Cummings

Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.

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ORCID record for Richard D. Cummings
For correspondence: dsteinh@emory.edu rcummin1@bidmc.harvard.edu

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Influenza binds phosphorylated glycans from human lung

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