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Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases

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Science Advances  27 Feb 2019:
Vol. 5, no. 2, eaav4322
DOI: 10.1126/sciadv.aav4322

Article Information

vol. 5 no. 2

Online ISSN: 
History: 
  • Received for publication September 14, 2018
  • Accepted for publication January 14, 2019
  • .

Author Information

  1. Sahil Gulati1,2,3,
  2. Krzysztof Palczewski1,2,3,*,
  3. Andreas Engel4,
  4. Henning Stahlberg4,* and
  5. Lubomir Kovacik4
  1. 1Gavin Herbert Eye Institute and the Department of Ophthalmology, University of California, Irvine, 829 Health Sciences Road, Irvine, CA 92617, USA.
  2. 2Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
  3. 3Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, 1819 East 101st Street, Cleveland, OH 44106, USA.
  4. 4Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, Mattenstrasse 26, 4058 Basel, Switzerland.
  1. *Corresponding author. Email: kpalczew{at}uci.edu (K.P.); henning.stahlberg{at}unibas.ch (H.S.)

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