Research ArticleBIOCHEMISTRY
Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases
- View ORCID ProfileSahil Gulati1,2,3,
- View ORCID ProfileKrzysztof Palczewski1,2,3,*,
- View ORCID ProfileAndreas Engel4,
- View ORCID ProfileHenning Stahlberg4,* and
- View ORCID ProfileLubomir Kovacik4
- 1Gavin Herbert Eye Institute and the Department of Ophthalmology, University of California, Irvine, 829 Health Sciences Road, Irvine, CA 92617, USA.
- 2Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
- 3Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, 1819 East 101st Street, Cleveland, OH 44106, USA.
- 4Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, Mattenstrasse 26, 4058 Basel, Switzerland.
- ↵*Corresponding author. Email: kpalczew{at}uci.edu (K.P.); henning.stahlberg{at}unibas.ch (H.S.)
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Science Advances 27 Feb 2019:
Vol. 5, no. 2, eaav4322
DOI: 10.1126/sciadv.aav4322
Vol. 5, no. 2, eaav4322
DOI: 10.1126/sciadv.aav4322
Sahil Gulati
1Gavin Herbert Eye Institute and the Department of Ophthalmology, University of California, Irvine, 829 Health Sciences Road, Irvine, CA 92617, USA.
2Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
3Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, 1819 East 101st Street, Cleveland, OH 44106, USA.
Krzysztof Palczewski
1Gavin Herbert Eye Institute and the Department of Ophthalmology, University of California, Irvine, 829 Health Sciences Road, Irvine, CA 92617, USA.
2Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
3Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, 1819 East 101st Street, Cleveland, OH 44106, USA.
Andreas Engel
4Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, Mattenstrasse 26, 4058 Basel, Switzerland.
Henning Stahlberg
4Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, Mattenstrasse 26, 4058 Basel, Switzerland.
Lubomir Kovacik
4Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, Mattenstrasse 26, 4058 Basel, Switzerland.
