Research ArticleCANCER
The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation
- View ORCID ProfileXi Jin1,2,3,*,
- View ORCID ProfileXiao-En Xu1,2,3,4,*,†,
- View ORCID ProfileYi-Zhou Jiang1,2,3,4,*,
- Yi-Rong Liu1,2,3,
- Wei Sun1,2,3,
- Ya-Jie Guo1,2,3,
- Yi-Xing Ren1,2,3,
- Wen-Jia Zuo1,2,3,4,
- Xin Hu1,2,3,4,
- Sheng-Lin Huang3,4,5,
- Hong-Jie Shen6,
- Fei Lan6,
- Yun-Fei He7,
- View ORCID ProfileGuo-Hong Hu7,
- Gen-Hong Di1,2,3,4,
- View ORCID ProfileXiang-Huo He3,4,5,
- View ORCID ProfileDa-Qiang Li3,4,5,
- View ORCID ProfileSuling Liu1,2,5,†,
- View ORCID ProfileKe-Da Yu1,2,3,4,† and
- View ORCID ProfileZhi-Ming Shao1,2,3,4,†
- 1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
- 2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
- 3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
- 4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
- 5Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China.
- 6Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Key Laboratory of Epigenetics, Department of Cellular and Genetic Medicine, School of Basic Medical Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P. R. China.
- 7The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
- ↵†Corresponding author. Email: zhimingshao{at}yahoo.com (Z.-M.S.); xiaoenxu{at}163.com (X.-E.X.); yukeda{at}163.com (K.-D.Y.); suling{at}fudan.edu.cn (S.L.)
↵* These authors contributed equally to this work.
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Science Advances 06 Mar 2019:
Vol. 5, no. 3, eaat9820
DOI: 10.1126/sciadv.aat9820
Vol. 5, no. 3, eaat9820
DOI: 10.1126/sciadv.aat9820
Xi Jin
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
Xiao-En Xu
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
Yi-Zhou Jiang
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
Yi-Rong Liu
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
Wei Sun
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
Ya-Jie Guo
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
Yi-Xing Ren
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
Wen-Jia Zuo
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
Xin Hu
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
Sheng-Lin Huang
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
5Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China.
Hong-Jie Shen
6Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Key Laboratory of Epigenetics, Department of Cellular and Genetic Medicine, School of Basic Medical Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P. R. China.
Fei Lan
6Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Key Laboratory of Epigenetics, Department of Cellular and Genetic Medicine, School of Basic Medical Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P. R. China.
Yun-Fei He
7The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
Guo-Hong Hu
7The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
Gen-Hong Di
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
Xiang-Huo He
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
5Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China.
Da-Qiang Li
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
5Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China.
Suling Liu
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
5Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China.
Ke-Da Yu
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
Zhi-Ming Shao
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
2Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.
3Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.
4Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.