Research ArticleCELL BIOLOGY

A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair

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Science Advances  06 Mar 2019:
Vol. 5, no. 3, eaau7566
DOI: 10.1126/sciadv.aau7566

Article Information

vol. 5 no. 3

Online ISSN: 
History: 
  • Received for publication August 8, 2018
  • Accepted for publication January 23, 2019
  • .

Author Information

  1. Weizhe Li1,*,
  2. Hong-Yan Wang1,*,
  3. Xiaolu Zhao1,
  4. Hongguo Duan1,
  5. Binghua Cheng2,
  6. Yafei Liu1,
  7. Mengjie Zhao1,
  8. Wenjie Shu1,
  9. Yuchao Mei1,
  10. Zengqi Wen3,
  11. Mingliang Tang1,
  12. Lin Guo4,
  13. Guohong Li3,
  14. Qiang Chen2,
  15. Xiaoqi Liu5,6 and
  16. Hai-Ning Du1,
  1. 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
  2. 2Medical Research Institute, School of Medicine, Wuhan University, Wuhan 430071, China.
  3. 3National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,Beijing 100101, China.
  4. 4State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
  5. 5Department of Biochemistry, Purdue University, West Lafayette, IN, USA.
  6. 6Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
  1. Corresponding author. Email: hainingdu{at}whu.edu.cn
  • * These authors contributed equally to this work.

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