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Research ArticleCELL BIOLOGY
A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair
- View ORCID ProfileWeizhe Li1,*,
- View ORCID ProfileHong-Yan Wang1,*,
- Xiaolu Zhao1,
- Hongguo Duan1,
- Binghua Cheng2,
- Yafei Liu1,
- Mengjie Zhao1,
- Wenjie Shu1,
- Yuchao Mei1,
- Zengqi Wen3,
- Mingliang Tang1,
- View ORCID ProfileLin Guo4,
- Guohong Li3,
- View ORCID ProfileQiang Chen2,
- Xiaoqi Liu5,6 and
- View ORCID ProfileHai-Ning Du1,†
- 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
- 2Medical Research Institute, School of Medicine, Wuhan University, Wuhan 430071, China.
- 3National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,Beijing 100101, China.
- 4State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
- 5Department of Biochemistry, Purdue University, West Lafayette, IN, USA.
- 6Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
- ↵†Corresponding author. Email: hainingdu{at}whu.edu.cn
↵* These authors contributed equally to this work.
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Science Advances 06 Mar 2019:
Vol. 5, no. 3, eaau7566
DOI: 10.1126/sciadv.aau7566
Vol. 5, no. 3, eaau7566
DOI: 10.1126/sciadv.aau7566
Weizhe Li
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Hong-Yan Wang
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Xiaolu Zhao
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Hongguo Duan
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Binghua Cheng
2Medical Research Institute, School of Medicine, Wuhan University, Wuhan 430071, China.
Yafei Liu
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Mengjie Zhao
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Wenjie Shu
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Yuchao Mei
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Zengqi Wen
3National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,Beijing 100101, China.
Mingliang Tang
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Lin Guo
4State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Guohong Li
3National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,Beijing 100101, China.
Qiang Chen
2Medical Research Institute, School of Medicine, Wuhan University, Wuhan 430071, China.
Xiaoqi Liu
5Department of Biochemistry, Purdue University, West Lafayette, IN, USA.
6Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
Hai-Ning Du
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
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