Research ArticleCELL BIOLOGY
A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair
- Weizhe Li1,*,
- Hong-Yan Wang1,*,
- Xiaolu Zhao1,
- Hongguo Duan1,
- Binghua Cheng2,
- Yafei Liu1,
- Mengjie Zhao1,
- Wenjie Shu1,
- Yuchao Mei1,
- Zengqi Wen3,
- Mingliang Tang1,
- Lin Guo4,
- Guohong Li3,
- Qiang Chen2,
- Xiaoqi Liu5,6 and
- Hai-Ning Du1,†
- 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
- 2Medical Research Institute, School of Medicine, Wuhan University, Wuhan 430071, China.
- 3National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,Beijing 100101, China.
- 4State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
- 5Department of Biochemistry, Purdue University, West Lafayette, IN, USA.
- 6Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
- ↵†Corresponding author. Email: hainingdu{at}whu.edu.cn
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Science Advances 06 Mar 2019:
Vol. 5, no. 3, eaau7566
DOI: 10.1126/sciadv.aau7566
