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Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease

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Science Advances  20 Mar 2019:
Vol. 5, no. 3, eaav0316
DOI: 10.1126/sciadv.aav0316

Article Information

vol. 5 no. 3

Online ISSN: 
History: 
  • Received for publication August 7, 2018
  • Accepted for publication January 31, 2019
  • .

Author Information

  1. Jong-Hyun Park1,*,
  2. Yeon Ha Ju2,3,4,*,
  3. Ji Won Choi1,
  4. Hyo Jung Song1,
  5. Bo Ko Jang1,
  6. Junsung Woo2,4,
  7. Heejung Chun4,
  8. Hyeon Jeong Kim1,5,
  9. Su Jeong Shin1,5,
  10. Oleg Yarishkin2,
  11. Seonmi Jo2,
  12. Mijeong Park6,
  13. Seul Ki Yeon1,5,
  14. Siwon Kim1,3,
  15. Jeongyeon Kim2,
  16. Min-Ho Nam2,4,
  17. Ashwini M. Londhe1,3,
  18. Jina Kim7,
  19. Sung Jin Cho7,
  20. Suengmok Cho8,
  21. Changho Lee8,
  22. Sung Yeoun Hwang9,
  23. Sang Wook Kim9,
  24. Soo-Jin Oh1,4,
  25. Jeiwon Cho6,
  26. Ae Nim Pae1,3,
  27. C. Justin Lee2,3,4,10, and
  28. Ki Duk Park1,3,11,
  1. 1Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
  2. 2Center for Neuroscience and Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
  3. 3Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.
  4. 4Center for Glia-Neuron Interaction, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
  5. 5Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
  6. 6Department of Medical Science, College of Medicine, Catholic Kwandong University and International St. Mary’s Hospital, Incheon 22711, Republic of Korea.
  7. 7New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.
  8. 8Department of Food Science and Technology, Pukyong National University, Busan 48513, Republic of Korea.
  9. 9KEMIMEDI & MEGABIOWOOD, 5F Hanil Bldg, Nonhyeon-ro 652, Seoul 06106, Republic of Korea.
  10. 10Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Republic of Korea.
  11. 11KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea.
  1. Corresponding author. Email: cjl{at}kist.re.kr (C.J.L.); kdpark{at}kist.re.kr (K.D.P.)
  • * These authors contributed equally to this work.

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Mar 2019562781564
Apr 2019791362335
May 2019291305192
Jun 201924104788
Jul 2019361144127
Aug 201915446117
Sep 201924443129
Oct 201921481114
Nov 2019614630

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