Research ArticleSTRUCTURAL BIOLOGY

Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR

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Science Advances  13 Mar 2019:
Vol. 5, no. 3, eaav8945
DOI: 10.1126/sciadv.aav8945

Article Information

vol. 5 no. 3

Online ISSN: 
History: 
  • Received for publication October 31, 2018
  • Accepted for publication January 28, 2019
  • .

Author Information

  1. Yuki Toyama1,2,
  2. Kenji Kontani3,
  3. Toshiaki Katada4 and
  4. Ichio Shimada1,*
  1. 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  2. 2Japan Biological Informatics Consortium (JBiC), Aomi, Koto-ku, Tokyo 135-0064, Japan.
  3. 3Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan.
  4. 4Molecular Cell Biology Laboratory, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Tokyo 202-8585, Japan.
  1. *Corresponding author. Email: shimada{at}iw-nmr.f.u-tokyo.ac.jp

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