Contribution of biomimetic collagen-ligand interaction to intrafibrillar mineralization

Q. Song; K. Jiao; L. Tonggu; L. G. Wang; S. L. Zhang; Y. D. Yang; L. Zhang; J. H. Bian; D. X. Hao; C. Y. Wang; Y. X. Ma; D. D. Arola; L. Breschi; J. H. Chen; F. R. Tay; L. N. Niu

doi:10.1126/sciadv.aav9075

Research ArticleMATERIALS SCIENCE

Contribution of biomimetic collagen-ligand interaction to intrafibrillar mineralization

Q. Song¹,*,
K. Jiao ¹,*,
L. Tonggu²,
L. G. Wang²,
S. L. Zhang³,
Y. D. Yang⁴,
L. Zhang³,
J. H. Bian⁴,
D. X. Hao³,
C. Y. Wang¹,
Y. X. Ma¹,
D. D. Arola⁵,
L. Breschi⁶,
J. H. Chen ¹,†,
F. R. Tay¹,⁷,† and
L. N. Niu ¹,†

¹State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical University, Xi’ an, Shaanxi, PR China.
²Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA, USA.
³Department of Applied Physics, Xi'an Jiaotong University, Xi’an, Shaanxi, PR China.
⁴Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an, Shaanxi, PR China.
⁵Department of Materials Science & Engineering, University of Washington, Seattle, WA, USA.
⁶Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
⁷College of Dental Medicine, Augusta University, Augusta, GA, USA.

↵†Corresponding author. Email: jhchen{at}fmmu.edu.cn (J.H.C.); ftay{at}augusta.edu (F.R.T.); niulina831013{at}126.com (L.N.N.)

↵* These authors contributed equally to this work.

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Science Advances 29 Mar 2019:
Vol. 5, no. 3, eaav9075
DOI: 10.1126/sciadv.aav9075

Q. Song

1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical University, Xi’ an, Shaanxi, PR China.

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K. Jiao

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L. Tonggu

2Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA, USA.

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L. G. Wang

2Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA, USA.

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S. L. Zhang

3Department of Applied Physics, Xi'an Jiaotong University, Xi’an, Shaanxi, PR China.

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Y. D. Yang

4Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an, Shaanxi, PR China.

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L. Zhang

3Department of Applied Physics, Xi'an Jiaotong University, Xi’an, Shaanxi, PR China.

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J. H. Bian

4Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an, Shaanxi, PR China.

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D. X. Hao

3Department of Applied Physics, Xi'an Jiaotong University, Xi’an, Shaanxi, PR China.

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C. Y. Wang

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Y. X. Ma

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D. D. Arola

5Department of Materials Science & Engineering, University of Washington, Seattle, WA, USA.

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L. Breschi

6Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.

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J. H. Chen

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For correspondence: jhchen@fmmu.edu.cn ftay@augusta.edu niulina831013@126.com

F. R. Tay

7College of Dental Medicine, Augusta University, Augusta, GA, USA.

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For correspondence: jhchen@fmmu.edu.cn ftay@augusta.edu niulina831013@126.com

L. N. Niu

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For correspondence: jhchen@fmmu.edu.cn ftay@augusta.edu niulina831013@126.com

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