Research ArticleBIOPHYSICS

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

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Science Advances  17 Apr 2019:
Vol. 5, no. 4, eaau3112
DOI: 10.1126/sciadv.aau3112

Article Information

vol. 5 no. 4

Online ISSN: 
History: 
  • Received for publication May 28, 2018
  • Accepted for publication February 27, 2019
  • .

Author Information

  1. Tom Scheidt1,
  2. Urszula Łapińska1,
  3. Janet R. Kumita1,
  4. Daniel R. Whiten1,2,
  5. David Klenerman1,
  6. Mark R. Wilson2,
  7. Samuel I. A. Cohen1,
  8. Sara Linse3,
  9. Michele Vendruscolo1,
  10. Christopher M. Dobson1,
  11. Tuomas P. J. Knowles1,4,* and
  12. Paolo Arosio1,5,*
  1. 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
  2. 2School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia.
  3. 3Department of Biochemistry and Structural Biology, Lund University, Box 124, SE221 00 Lund, Sweden.
  4. 4Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK.
  5. 5Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg, 8093 Zurich, Switzerland.
  1. *Corresponding author. Email: tpjk2{at}cam.ac.uk (T.P.J.K.); paolo.arosio{at}chem.ethz.ch (P.A.)

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