Structure and mechanisms of sodium-pumping KR2 rhodopsin

Kirill Kovalev; Vitaly Polovinkin; Ivan Gushchin; Alexey Alekseev; Vitaly Shevchenko; Valentin Borshchevskiy; Roman Astashkin; Taras Balandin; Dmitry Bratanov; Svetlana Vaganova; Alexander Popov; Vladimir Chupin; Georg Büldt; Ernst Bamberg; Valentin Gordeliy

doi:10.1126/sciadv.aav2671

Research ArticleMOLECULAR BIOLOGY

Structure and mechanisms of sodium-pumping KR2 rhodopsin

Kirill Kovalev¹,²,³,⁴,*,
Vitaly Polovinkin¹,²,*,
Ivan Gushchin³,
Alexey Alekseev²,³,⁴,
Vitaly Shevchenko²,³,⁴,
Valentin Borshchevskiy³,
Roman Astashkin¹,³,
Taras Balandin²,
Dmitry Bratanov¹,²,
Svetlana Vaganova²,
Alexander Popov⁵,
Vladimir Chupin³,
Georg Büldt³,
Ernst Bamberg³,⁶,† and
Valentin Gordeliy¹,²,³,†

¹Institut de Biologie Structurale, Université Grenoble Alpes-CEA-CNRS, Grenoble, France.
²Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.
³Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.
⁴Institute of Crystallography, University of Aachen (RWTH), Aachen, Germany.
⁵European Synchrotron Radiation Facility, 38043 Grenoble, France.
⁶Max Planck Institute of Biophysics, Frankfurt am Main, Germany.

↵†Corresponding author. Email: valentin.gordeliy{at}ibs.fr (V.G.); ernst.bamberg{at}biophys.mpg.de (E.B.)

↵* These authors contributed equally to this work.

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Science Advances 10 Apr 2019:
Vol. 5, no. 4, eaav2671
DOI: 10.1126/sciadv.aav2671

Kirill Kovalev

Institut de Biologie Structurale, Université Grenoble Alpes-CEA-CNRS, Grenoble, France.

Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

Institute of Crystallography, University of Aachen (RWTH), Aachen, Germany.

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Vitaly Polovinkin

Institut de Biologie Structurale, Université Grenoble Alpes-CEA-CNRS, Grenoble, France.

Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

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Ivan Gushchin

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

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Alexey Alekseev

Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

Institute of Crystallography, University of Aachen (RWTH), Aachen, Germany.

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Vitaly Shevchenko

Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

Institute of Crystallography, University of Aachen (RWTH), Aachen, Germany.

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Valentin Borshchevskiy

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

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Roman Astashkin

Institut de Biologie Structurale, Université Grenoble Alpes-CEA-CNRS, Grenoble, France.

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

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Taras Balandin

Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

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Dmitry Bratanov

Institut de Biologie Structurale, Université Grenoble Alpes-CEA-CNRS, Grenoble, France.

Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

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Svetlana Vaganova

Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

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Alexander Popov

European Synchrotron Radiation Facility, 38043 Grenoble, France.

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Vladimir Chupin

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

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Georg Büldt

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

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Ernst Bamberg

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

Max Planck Institute of Biophysics, Frankfurt am Main, Germany.

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For correspondence: valentin.gordeliy@ibs.fr ernst.bamberg@biophys.mpg.de

Valentin Gordeliy

Institut de Biologie Structurale, Université Grenoble Alpes-CEA-CNRS, Grenoble, France.

Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia.

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ORCID record for Valentin Gordeliy
For correspondence: valentin.gordeliy@ibs.fr ernst.bamberg@biophys.mpg.de

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