In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway

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Science Advances  17 Apr 2019:
Vol. 5, no. 4, eaav3335
DOI: 10.1126/sciadv.aav3335

Article Information

vol. 5 no. 4

Online ISSN: 
  • Received for publication September 6, 2018
  • Accepted for publication March 1, 2019
  • .

Author Information

  1. Yuan Cai1,*,
  2. Tianlin Cheng2,*,
  3. Yichuan Yao1,*,
  4. Xiao Li2,
  5. Yuqian Ma1,
  6. Lingyun Li1,
  7. Huan Zhao1,3,
  8. Jin Bao1,
  9. Mei Zhang1,,
  10. Zilong Qiu2,4, and
  11. Tian Xue1,4,5,
  1. 1Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
  2. 2Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China.
  3. 3Department of Biological and Environmental Engineering, Hefei University, Hefei 230601, China.
  4. 4Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
  5. 5Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
  1. Corresponding author. Email: xuetian{at} (T.X.); zqiu{at} (Z.Q.); zhangmei{at} (M.Z.)
  • * These authors contributed equally to this work.


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