Research ArticleNEUROSCIENCE

Imaging localized neuronal activity at fast time scales through biomechanics

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Science Advances  17 Apr 2019:
Vol. 5, no. 4, eaav3816
DOI: 10.1126/sciadv.aav3816

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  • RE: Response to Hetzer et al
    • Samuel Patz, Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USA

     

    Response to Letter to the Editor

     

    Submitted by Hetzer et al. [1] regarding our Science Advances paper [2] titled:

    Imaging localized neuronal activity at fast time scales through biomechanics.

     

    Samuel Patz1,2, Daniel Fovargue3, David Nordsletten3,4 and Ralph Sinkus3,5

     

    1Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USA

    2Harvard Medical School, Boston, MA, USA.

    3School of Biomedical Engineering and Imaging Sciences, Kings College London, London, UK

    4Department of Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA

    5Inserm U1148, LVTS, University Paris Diderot, University Paris 13, Paris, France

     

    Corresponding authors:

    Samuel Patz: patz@bwh.harvard.edu

    Ralph Sinkus: ralph.sinkus@inserm.fr

     

    We appreciate Hetzer et al.'s thorough analysis of our work. This is a good example of how results are vetted in the scientific community. Hetzer et al. make critiques regarding the validity of our observations, leading them to claim that our observation of a functionally mediated change in brain tissue stiffness is unfounded. Below we provide a rebuttal of these serious critiques, as well as their more minor concerns, d...

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    Competing Interests: None declared.
  • Response to Imaging localized neuronal activity at fast time scales through biomechanics
    • Stefan Hetzer, Berlin Center for Advanced Neuroimaging Charité – Universitätsmedizin Berlin

    Letter to the Editor

     

    Stefan Hetzer1,2, Carsten Allefeld3, Sebastian Hirsch1,2, Philipp Boehm-Sturm4,5, Ulrich Dirnagl4,6

     

    1Berlin Center for Advanced Neuroimaging, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

    2Bernstein Center for Computational Neuroscience, Berlin, Germany

    3Department of Psychology, City, University of London, London, UK

    4Department of Experimental Neurology and Center for Stroke Research, Charité – Universitätsmedizin Berlin, Berlin, Germany

    5NeuroCure Cluster of Excellence and Charité Core Facility 7T Experimental MRIs, Charité – Universitätsmedizin Berlin, Berlin, Germany

    6QUEST Center, Berlin Institute of Health, Berlin, Germany

     

    Correspondence address:

     

    Dr. Stefan Hetzer

    Berlin Center for Advanced Neuroimaging

    Charité – Universitätsmedizin Berlin

    Charitéplatz 1

    10117 Berlin, Germany

    stefan.hetzer@charite.de

    Tel +49 30 450 539353

     

     

    Competing Interests:  N...

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    Competing Interests: None declared.

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