Research ArticleCELL BIOLOGY
The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62
- View ORCID ProfileDaqian Xu1,2,
- Xinjian Li1,
- Fei Shao3,4,5,
- Guishuai Lv6,7,
- Hongwei Lv6,7,
- Jong-Ho Lee1,
- Xu Qian8,
- Zheng Wang9,
- Yan Xia1,
- Linyong Du10,
- View ORCID ProfileYanhua Zheng1,
- View ORCID ProfileHongyang Wang6,7,11,*,
- View ORCID ProfileJianxin Lyu10,12,* and
- View ORCID ProfileZhimin Lu1,13,*
- 1Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 2Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 3Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266061, China.
- 4Qingdao Cancer Institute, Qingdao, Shandong 266061, China.
- 5State Key Laboratory of Molecular Oncology, Department of Thoracic Surgery, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
- 6International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.
- 7National Center for Liver Cancer, Shanghai 201805, China.
- 8Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, 101 Longmian AV., Nanjing, Jiangsu 211166, China.
- 9Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA.
- 10Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
- 11State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University, Shanghai 200032, China.
- 12Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
- 13Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China.
- ↵*Corresponding author. Email: zhiminlu{at}zju.edu.cn (Z.L.); jxlu313{at}163.com (J.L.); hywangk{at}vip.sina.com (H.W.)
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Science Advances 24 Apr 2019:
Vol. 5, no. 4, eaav4570
DOI: 10.1126/sciadv.aav4570
Vol. 5, no. 4, eaav4570
DOI: 10.1126/sciadv.aav4570
Daqian Xu
1Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
2Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xinjian Li
1Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Fei Shao
3Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266061, China.
4Qingdao Cancer Institute, Qingdao, Shandong 266061, China.
5State Key Laboratory of Molecular Oncology, Department of Thoracic Surgery, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Guishuai Lv
6International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.
7National Center for Liver Cancer, Shanghai 201805, China.
Hongwei Lv
6International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.
7National Center for Liver Cancer, Shanghai 201805, China.
Jong-Ho Lee
1Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xu Qian
8Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, 101 Longmian AV., Nanjing, Jiangsu 211166, China.
Zheng Wang
9Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA.
Yan Xia
1Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Linyong Du
10Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Yanhua Zheng
1Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hongyang Wang
6International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.
7National Center for Liver Cancer, Shanghai 201805, China.
11State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University, Shanghai 200032, China.
Jianxin Lyu
10Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
12Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
Zhimin Lu
1Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
13Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China.
