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A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

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Science Advances  10 Apr 2019:
Vol. 5, no. 4, eaav4580
DOI: 10.1126/sciadv.aav4580

Article Information

vol. 5 no. 4

Online ISSN: 
History: 
  • Received for publication September 25, 2018
  • Accepted for publication February 14, 2019
  • .

Author Information

  1. Shuai Xia1,*,
  2. Lei Yan2,*,
  3. Wei Xu1,*,
  4. Anurodh Shankar Agrawal3,
  5. Abdullah Algaissi3,4,
  6. Chien-Te K. Tseng3,
  7. Qian Wang1,
  8. Lanying Du5,
  9. Wenjie Tan6,
  10. Ian A. Wilson2,7,,
  11. Shibo Jiang1,5,,
  12. Bei Yang2, and
  13. Lu Lu1,
  1. 1Shanghai Public Health Clinical Center and School of Basic Medical Sciences, and Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai 200032, China.
  2. 2Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
  3. 3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  4. 4Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
  5. 5Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
  6. 6MOH Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
  7. 7Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC206, La Jolla, CA 92037, USA.
  1. Corresponding author. Email: wilson{at}scripps.edu (I.A.W.); shibojiang{at}fudan.edu.cn (S.J.); yangbei{at}shanghaitech.edu.cn (B.Y.); lul{at}fudan.edu.cn (L.L.)
  • * These authors contributed equally to this work.

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