Research ArticleGENETICS

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse

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Science Advances  03 Apr 2019:
Vol. 5, no. 4, eaav9824
DOI: 10.1126/sciadv.aav9824

Article Information

vol. 5 no. 4

Online ISSN: 
History: 
  • Received for publication November 7, 2018
  • Accepted for publication February 11, 2019
  • .

Author Information

  1. R. Filograna1,2,
  2. C. Koolmeister1,2,
  3. M. Upadhyay1,2,
  4. A. Pajak1,2,
  5. P. Clemente1,2,
  6. R. Wibom3,
  7. M. L. Simard4,
  8. A. Wredenberg1,2,3,
  9. C. Freyer1,2,3,
  10. J. B. Stewart4 and
  11. N. G. Larsson1,2,3,4,*
  1. 1Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 76 Stockholm, Sweden.
  2. 2Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, S-171 77 Stockholm, Sweden.
  3. 3Center for Inherited Metabolic Diseases, Karolinska University Hospital, S-171 76 Stockholm, Sweden.
  4. 4Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany.
  1. *Corresponding author. Email: nils-goran.larsson{at}ki.se

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Oct 2019235681
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